Trial reportInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases2025
Effect of one prophylactic dose of azithromycin on Bifidobacterium infantis colonization in infants from the Mumta trial.
Trial report in International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- The effect of Akkermansia in patients with pregnancy induced hypertension.BMC microbiology · 2025Article
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Authors and funding
9 authors.
Funding
Abstract
objectivesThe effects of antibiotics on the microbiome remain incompletely understood. Azithromycin (AZ) has been shown to improve child survival and infant growth outcomes. This study aimed to assess the impact of AZ on Bifidobacterium infantis colonization and bacterial enteropathogen count in the infant gut.
methodsWe analyzed clinical, biomarker, B. infantis and enteropathogen data from 150 mother-infant dyads from the MUMTA Lactating Women study. Colonization of B. infantis was assessed using quantitative polymerase chain reaction (PCR) of fecal samples. We utilized a customized PCR-based TaqMan Array Card for enteropathogen detection.
resultsAZ administration was associated with a 1.99-fold (95% confidence intervals [CI] 1.33-2.97) increase in colonization by B. infantis. B. infantis colonization was highest when inflammatory biomarker levels were within normal range. Mode of delivery (RR 2.43; 95% CI: 1.58, 3.76) and colostrum (RR2.05; 95% CI: 1.41, 2.98) given to the infant within 24 h of birth were associated with B. infantis colonization. A single dose of AZ on day 42 reduced bacterial enteropathogen count in the AZ group on day 56, as compared to the pre-AZ count. Bacterial enteropathogen count for infants with wasting (weight for length z-score WLZ <-2) was 1.43-fold higher (95% CI: 1.00-2.03) than for infants with WLZ ≥ -2. Over 60% of infants harbored with the macrolide resistance mph(A) gene
conclusionAZ administration increases B. infantis colonization and reduces bacterial enteropathogen count in infants.
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