Evidence map›Paper›PMID 39854689›Full record

ArticlePancreas2025

Preoperative Anemia as a Prognostic Risk Factor for Inferior Oncological Survival Following Resection for Pancreatic Ductal Adenocarcinoma.

Mylena D Bos, N Helge Meyer, Allard G Wijma, Karl Khatib-Chahidi, Evert van den Broek, Cassandra S L Ho, Mark Meerdink, Joost M Klaase, Maximilian Bockhorn, Frederik J H Hoogwater and 1 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Pancreas, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

11 authors.

Mylena D BosDepartment of Surgery, Division of Hepato-Pancreato-Biliary Surgery and Liver Transplantation, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.ORCID 0000-0002-1913-483
N Helge MeyerDepartment of Human Medicine, University Hospital of General and Visceral Surgery, University of Oldenburg and Klinikum Oldenburg, Oldenburg, Germany.
Allard G WijmaDepartment of Surgery, Division of Hepato-Pancreato-Biliary Surgery and Liver Transplantation, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Karl Khatib-ChahidiDepartment of Human Medicine, University Hospital of General and Visceral Surgery, University of Oldenburg and Klinikum Oldenburg, Oldenburg, Germany.
Evert van den BroekDepartment of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Cassandra S L HoDepartment of Surgery, Division of Hepato-Pancreato-Biliary Surgery and Liver Transplantation, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Mark MeerdinkDepartment of Surgery, Division of Hepato-Pancreato-Biliary Surgery and Liver Transplantation, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Joost M KlaaseDepartment of Surgery, Division of Hepato-Pancreato-Biliary Surgery and Liver Transplantation, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Maximilian BockhornDepartment of Human Medicine, University Hospital of General and Visceral Surgery, University of Oldenburg and Klinikum Oldenburg, Oldenburg, Germany.
Frederik J H HoogwaterDepartment of Surgery, Division of Hepato-Pancreato-Biliary Surgery and Liver Transplantation, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Maarten W NijkampDepartment of Surgery, Division of Hepato-Pancreato-Biliary Surgery and Liver Transplantation, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesA significant proportion of patients undergoing surgery for pancreatic ductal adenocarcinoma (PDAC) are anemic at the time of resection. In these patients, blood transfusions are omitted because of their potential negative impact on oncological outcomes. The present study aimed to determine the prognostic value of preoperative anemia in resected PDAC patients, irrespective of blood transfusion status. MATERIALS AND

methodsThis retrospective 2-center cohort study included patients who underwent resection for PDAC between 2013 and 2022. The prognostic role of preoperative anemia was investigated using Cox proportional-hazard regression analysis. A subgroup analysis excluded PDAC patients who received a perioperative blood transfusion.

resultsAmong 280 included PDAC patients, 110 (39%) were found to have preoperative anemia. Preoperative anemia was associated with increased use of blood transfusions, with 44 patients (16%) requiring transfusion perioperatively. In the whole cohort, preoperative anemia was an independent predictor of lower disease-free survival (hazard ratio [HR] = 1.518; 95% confidence interval [CI] = 1.103-2.090, P  = 0.011), but not overall survival. However, when patients who received a perioperative blood transfusion were excluded, preoperative anemia was independently associated with both lower disease-free survival (HR = 1.636; 95% CI = 1.113-2.404, P  = 0.012) and overall survival (HR = 1.484; 95% CI = 1.036-2.127, P  = 0.031).

conclusionsPreoperative anemia was identified as an independent risk factor for inferior oncological survival after resection for PDAC. These results support the need for increased awareness regarding the potential adverse effects of preoperative anemia on oncological outcomes in PDAC.

Indexed as

AnemiaCarcinoma, Pancreatic DuctalPancreatectomyPancreatic NeoplasmsAgedBlood TransfusionDisease-Free SurvivalFemaleHumansMaleMiddle AgedPreoperative PeriodPrognosisProportional Hazards ModelsRetrospective StudiesRisk Factorsanemiapancreatic ductal adenocarcinomaPDACprognostic factorrecurrencesurvival

Identifiers

PMID39854689
PMCPMC12052068

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