Evidence map›Paper›PMID 39854584›Full record

SynthesisPloS one2025

Virtual reality perimetry compared to standard automated perimetry in adults with glaucoma: A systematic review.

Natan Hekmatjah, Chimelie Chibututu, Ying Han, Jeremy D Keenan, Julius T Oatts

Abstract readSystematic ReviewComparative Study
In one paragraph

Synthesis in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Natan HekmatjahSchool of Medicine, University of California, San Francisco, San Francisco, California, United States of America.ORCID 0000-0003-2421-9616
Chimelie ChibututuUniversity of Michigan Medical School, Ann Arbor, Michigan, United States of America.
Ying HanFrancis I. Proctor Foundation, San Francisco, San Francisco, California, United States of America.
Jeremy D KeenanFrancis I. Proctor Foundation, San Francisco, San Francisco, California, United States of America.
Julius T OattsDivision of Ophthalmology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America.ORCID 0000-0002-3945-2077

Funding

Rapid-Prototyping and Design CoreP30EY002162 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ULLIAN, ERIK M · 1985 to 2024
$16.8M
Community-based amblyopia screening using a novel deviceK23EY034893 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Julius Oatts · 2023 to 2026
$1.0M
NEI NIH HHS K23 EY034893NEI NIH HHS P30 EY002162
6 · The paper itself

Abstract

purposeThe purpose of this systematic review was to consolidate and summarize available data comparing virtual reality perimetry (VRP) with standard automated perimetry (SAP) in adults with glaucoma. Understanding the utility and diagnostic performance of emerging VRP technology may expand access to visual field testing but requires evidence-based validation.

methodsA systematic literature search was conducted in 3 databases (PubMed Central, Embase, and Cochrane Central Register of Controlled Trials) from the date of inception to 10/09/2024. Eligibility criteria included randomized controlled trials or prospective or retrospective cohort studies that compared different modalities of VRP to SAP in adults >18 years of age with glaucoma. Studies were excluded if they were review articles, letters, case reports, abstract-only papers, unavailable full text, or non-English language. Identified studies were formally evaluated for risk of bias using the Newcastle-Ottawa tool. The study protocol was prospectively registered with PROSPERO in May 2023 (registration number: CRD42023429071).

resultsThe literature search yielded 1657 results. After deduplication, abstract and title screening, 14 studies met inclusion criteria and were included in the final systematic review. Compared to Humphrey Field Analyzer or Octopus 900, 10 different VRP devices were included in our study: Oculus Quest, Smartphone-based Campimetry, Toronto Portable Perimeter, VirtualEye, Advance Vision Analyzer, VisuALL, Vivid Vision Perimeter, C3 fields visual field analyzer, Radius, and Virtual Field. Overall, published studies of VRP are promising; however, more work is required to better evaluate these devices, namely test-retest repeatability.

conclusionsVRP holds strong potential to evaluate visual fields in adults with glaucoma, though further data is needed to validate emerging technologies and testing protocols. Eye providers may consider using these devices to monitor certain adults with glaucoma.

Indexed as

GlaucomaVirtual RealityVisual Field TestsAdultHumansVisual Fields

Identifiers

PMID39854584
PMCPMC11760034

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.