ArticleScience immunology2025
Coordinated immune networks in leukemia bone marrow microenvironments distinguish response to cellular therapy.
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Article in Science immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22citing papers in PubMed
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Who cites it
22 citing papers in PubMed.
- Synergistic immune interactions between T cells and natural killer cells in allogeneic haematopoietic stem cell transplantation for acute myeloid leukaemia: current status and future directions.Annals of medicine · 2026Review
- Spatiotemporal single-cell profiling reveals T cell clonal dynamics and phenotypic plasticity in human graft-versus-host disease.Nature immunology · 2026Article
- scRNA-Seq reveals anti-lymphoma immune responses in mogamulizumab-associated skin eruptions.Journal of the European Academy of Dermatology and Venereology : JEADV · 2026Article
- Donor lymphocyte infusion as immune modulation after pediatric allogeneic transplantation.Blood immunology & cellular therapy · 2026Article
- Single-cell profiling uncovers a hypoxia-vascular-immune axis underlying poor immunotherapy response in acral versus cutaneous melanoma.Journal of translational medicine · 2026Article
- Single-cell and spatial profiling in cancer biology and clinical oncology.Nature cancer · 2026Review
- Donor lymphocyte infusions for recurrence of myeloid neoplasms after allogeneic hematopoietic cell transplantation in the era of hypomethylating agents and BCL2 inhibitors.Annals of hematology · 2026Article
- Ovarian hormone deficiency enhances wood smoke-induced immune dysfunction via transcriptomic and metabolic alterations.Toxicological sciences : an official journal of the Society of Toxicology · 2026Article
- Single-cell profiling reveals reprogrammed hierarchy and disrupted immune-stromal ecosystem in TP53-mutated AML.Experimental hematology & oncology · 2026Article
- An expanded role for single-cell chemical genomics profiling in drug discovery.The Biochemical journal · 2026Review
- Ovarian hormone deficiency enhances wood smoke-induced immune dysfunction via transcriptomic and metabolic alterations.bioRxiv : the preprint server for biology · 2026Article
- Algorithmically defined therapeutic targets: integrating single-cell transfer learning frameworks with small molecule drugs to reverse disease-associated cell fates.Frontiers in pharmacology · 2026Review
- Dual relevance ofFrontiers in oncology · 2026Article
- Associations of polymorphisms in the myeloid immunoregulatory receptor gene MRC1 with expression and prognosis in acute myeloid leukemia.Frontiers in immunology · 2026Article
- Defining the role of natural killer cells in acute myeloid leukemia through the lens of single-cell omics.Frontiers in immunology · 2026Review
- Pre-treatment T cell features and immune-milieu characteristics shape treatment-induced exhaustion and resistance to Blinatumomab in B-cell acute lymphoblastic leukemia.Frontiers in immunology · 2026Article
- T lymphocytes and natural killer cells in myelodysplastic syndromes: function, dysfunction, and therapeutic potential.Frontiers in immunology · 2026Review
- Posttransplant cells for the win? DLI and adoptive cell therapy to eradicate MRD.Hematology. American Society of Hematology. Education Program · 2025Review
- Mega-scale single-cell profiling reveals novel biomarkers associated with acute GvHD after allogeneic hematopoietic stem cell transplantation.Biomarker research · 2025Article
- The prognostic marker NRIP1 is associated with tumor progression and immune infiltration in acute myeloid leukemia.Acta biochimica et biophysica Sinica · 2025Article
Corrections and comments
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Authors and funding
30 authors.
Katie MaurerDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.ORCID 0000-0002-4160-181X
Cameron Y ParkIrving Institute for Cancer Dynamics, Columbia University, New York, NY 10027, USA.ORCID 0009-0003-0004-7714
Shouvik ManiIrving Institute for Cancer Dynamics, Columbia University, New York, NY 10027, USA.ORCID 0009-0001-9295-9651
Mehdi BorjiDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.ORCID 0009-0002-7023-434X
Florian RathsSingular Genomics, San Diego, CA 92121, USA.
Kenneth H GouinSingular Genomics, San Diego, CA 92121, USA.ORCID 0000-0003-2657-0549
Livius PenterDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.ORCID 0000-0002-9060-0207
Yinuo JinIrving Institute for Cancer Dynamics, Columbia University, New York, NY 10027, USA.
Jia Yi ZhangIrving Institute for Cancer Dynamics, Columbia University, New York, NY 10027, USA.
Crystal ShinIrving Institute for Cancer Dynamics, Columbia University, New York, NY 10027, USA.
James R BrennerDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.ORCID 0009-0003-0724-1376
Jackson SouthardDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.ORCID 0000-0002-3025-9406
Sachi KrishnaSpatial Technology Platform, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID 0000-0002-7457-9700
Wesley LuDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.ORCID 0009-0007-5584-041X
Haoxiang LyuDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.ORCID 0000-0003-0165-9934
Domenic AbbondanzaSpatial Technology Platform, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID 0000-0002-7202-0225
Chanell MangumSpatial Technology Platform, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID 0000-0002-7852-2840
Lars Rønn OlsenDepartment of Health Technology, Technical University of Denmark, 2800 Kongens Lyngby, Denmark.ORCID 0000-0002-6725-7850
Michael J LawsonSingular Genomics, San Diego, CA 92121, USA.ORCID 0000-0002-2868-733X
Martin FabaniSingular Genomics, San Diego, CA 92121, USA.
Donna S NeubergDepartment of Data Science, Dana-Farber Cancer Institute, Boston, MA 02215, USA.ORCID 0000-0003-2566-3145
Pavan BachireddyDepartment of Hematopoietic Biology & Malignancy, MD Anderson Cancer Center, Houston, TX 77030, USA.ORCID 0000-0002-8698-4957
Eli N GlezerSingular Genomics, San Diego, CA 92121, USA.
Samouil L FarhiSpatial Technology Platform, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID 0000-0003-1359-4568
Shuqiang LiDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Kenneth J LivakDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.ORCID 0000-0001-9105-5856
Jerome RitzDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.ORCID 0000-0001-5526-4669
Robert J SoifferDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.ORCID 0000-0002-5810-1192
Catherine J WuDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.ORCID 0000-0002-3348-5054
Elham AziziIrving Institute for Cancer Dynamics, Columbia University, New York, NY 10027, USA.ORCID 0000-0001-5059-6971
Funding
TYROSINE KINASE ONCOGENESIS IN MYELOID LEUKEMIAP01CA066996 · NCI · DANA-FARBER CANCER INSTITUTE · PI SCOTT A ARMSTRONG · 1996 to 2026
$52.5MSingle Cell Analysis and ImmunogeneticsP01HL158505 · NHLBI · DANA-FARBER CANCER INST · PI Corey S Cutler · 2022 to 2026
$15.3MMachine learning methods for interpreting spatial multi-omics dataR01HG012875 · NHGRI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Elham Azizi · 2023 to 2026
$1.7MSingle cell investigation of co-evolution in cancer cells and host cell immune microenvironmentR50CA251956 · NCI · DANA-FARBER CANCER INST · PI Shuqiang Li · 2020 to 2026
$1.4MElucidating Human Leukemia and T Cell Interactions within the Tumor MicroenvironmentK08CA248458 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI BACHIREDDY, PAVAN · 2020 to 2024
$1.1MIntegrative framework for identifying dysregulated mechanisms in the tumor-immune microenvironmentR00CA230195 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI AZIZI, ELHAM · 2020 to 2022
$652kNCI NIH HHS K08 CA248458NCI NIH HHS P01 CA066996NCI NIH HHS R00 CA230195NCI NIH HHS R50 CA251956NHGRI NIH HHS R01 HG012875NHLBI NIH HHS P01 HL158505
Abstract
Understanding how intratumoral immune populations coordinate antitumor responses after therapy can guide treatment prioritization. We systematically analyzed an established immunotherapy, donor lymphocyte infusion (DLI), by assessing 348,905 single-cell transcriptomes from 74 longitudinal bone marrow samples of 25 patients with relapsed leukemia; a subset was evaluated by both protein- and transcriptome-based spatial analysis. In acute myeloid leukemia (AML) DLI responders, we identified clonally expanded
Indexed as
Bone MarrowLeukemia, Myeloid, AcuteTumor MicroenvironmentAdultFemaleHumansMaleMiddle AgedT-Lymphocytes, Cytotoxic
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.