Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
19 authors.
Prakash P PraharajChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.ORCID 0000-0003-0425-5118
Yang LiDepartment of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0001-9601-4885
Charline MaryAtelier de Biologie Chimie Informatique Structurale, Centre de Biologie Structurale, Univ Montpellier, CNRS, INSERM, 29 rue de Navacelles, 34090 Montpellier, France.
Mona H SoflaeeChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.ORCID 0000-0003-4598-3955
Kevin RyuChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.ORCID 0009-0005-8836-2720
Dohun KimChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.ORCID 0000-0002-6060-0601
Diem H TranChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.ORCID 0000-0003-3612-1464
Trishna DeyChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.ORCID 0000-0002-5504-2481
Harrison J TomChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.ORCID 0000-0001-9402-2371
Halie RionChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.ORCID 0000-0002-7827-6352
Muriel GelinAtelier de Biologie Chimie Informatique Structurale, Centre de Biologie Structurale, Univ Montpellier, CNRS, INSERM, 29 rue de Navacelles, 34090 Montpellier, France.ORCID 0000-0003-1320-8663
Andrew LemoffDepartment of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Lauren G ZachariasChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.
João S PatricioChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.ORCID 0000-0001-7045-4532
Thomas P MathewsChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.ORCID 0000-0002-9355-8243
Zhe ChenDepartment of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-1668-4051
Corinne LionneAtelier de Biologie Chimie Informatique Structurale, Centre de Biologie Structurale, Univ Montpellier, CNRS, INSERM, 29 rue de Navacelles, 34090 Montpellier, France.ORCID 0000-0002-6348-5311
Gerta HoxhajChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.ORCID 0000-0001-6179-3583
Gilles LabesseAtelier de Biologie Chimie Informatique Structurale, Centre de Biologie Structurale, Univ Montpellier, CNRS, INSERM, 29 rue de Navacelles, 34090 Montpellier, France.ORCID 0000-0002-6861-3300
Funding
UT Southwestern NORCP30DK127984 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI Jeffrey M Zigman · 2022 to 2026
$7.4M
Revealing the essential functions of mitochondrial NADPH and NADK2 for cell growth and proliferationR01GM143236 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI HOXHAJ, GERTA N/A · 2021 to 2025
$1.8M
OneMP Mass PhotometerS10OD030312 · OD · UT SOUTHWESTERN MEDICAL CENTER · PI BRAUTIGAM, CHAD · 2021 to 2021
Reduced nicotinamide adenine dinucleotide phosphate (NADPH) is a crucial reducing cofactor for reductive biosynthesis and protection from oxidative stress. To fulfill their heightened anabolic and reductive power demands, cancer cells must boost their NADPH production. Progrowth and mitogenic protein kinases promote the activity of cytosolic NAD kinase (NADK), which produces NADP
Indexed as
Cryoelectron MicroscopyPhosphotransferases (Alcohol Group Acceptor)HumansModels, MolecularNADNADPProtein BindingProtein ConformationNADNAD kinaseNADPPhosphotransferases (Alcohol Group Acceptor)
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Cryo-EM structure and regulation of human NAD kinase. · full record | OpenQuestion