Evidence map›Paper›PMID 39854462›Full record

ArticleScience advances2025

Massively parallel barcode sequencing revealed the interchangeability of capsule transporters in

Wan-Zhen Chua, Rachel Lyn Ee Wong, Ye-Yu Chun, Nicole Ng Chyi Shien, Tong Su, Matthias Maiwald, Kean Lee Chew, Raymond Tzer-Pin Lin, Alyson M Hockenberry, Min Luo and 1 more

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Wan-Zhen ChuaInfectious Diseases Translational Research Programme and Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.ORCID 0000-0001-9714-8463
Rachel Lyn Ee WongInfectious Diseases Translational Research Programme and Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Ye-Yu ChunInfectious Diseases Translational Research Programme and Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.ORCID 0000-0002-2048-1337
Nicole Ng Chyi ShienInfectious Diseases Translational Research Programme and Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.ORCID 0009-0000-8069-2577
Tong SuInfectious Diseases Translational Research Programme and Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.ORCID 0000-0003-0685-7972
Matthias MaiwaldInfectious Diseases Translational Research Programme and Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.ORCID 0000-0001-5448-8417
Kean Lee ChewDepartment of Laboratory Medicine, National University Hospital, Singapore, Singapore.ORCID 0000-0002-2234-4299
Raymond Tzer-Pin LinInfectious Diseases Translational Research Programme and Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.ORCID 0000-0001-6654-026X
Alyson M HockenberryInfectious Diseases Translational Research Programme and Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.ORCID 0000-0003-0828-1428
Min LuoDepartment of Biological Sciences, Faculty of Science, National University of Singapore, Singapore, Singapore.ORCID 0000-0002-3493-2282
Lok-To ShamInfectious Diseases Translational Research Programme and Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.ORCID 0000-0001-9047-0310

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) family transporters are essential in glycan synthesis, flipping lipid-linked precursors across cell membranes. Yet, how they select their substrates remains enigmatic. Here, we investigate the substrate specificity of the MOP transporters in the capsular polysaccharide (CPS) synthesis pathway in

Indexed as

Bacterial CapsulesBacterial ProteinsHigh-Throughput Nucleotide SequencingMembrane Transport ProteinsStreptococcus pneumoniaeBiological TransportSubstrate SpecificityBacterial ProteinsMembrane Transport Proteins

Identifiers

PMID39854462
PMCPMC11759038

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.