Evidence map›Paper›PMID 39854459›Full record

ArticleScience advances2025

The oxygen level in air directs airway epithelial cell differentiation by controlling mitochondrial citrate export.

Bo Ram Kim, Adam J Rauckhorst, Michael S Chimenti, Tayyab Rehman, Henry L Keen, Philip H Karp, Eric B Taylor, Michael J Welsh

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Bo Ram KimDepartment of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, USA.ORCID 0009-0006-6696-332X
Adam J RauckhorstPappajohn Biomedical Institute, University of Iowa Carver College of Medicine, Iowa City, IA, USA.ORCID 0000-0002-4101-0075
Michael S ChimentiIowa Institute of Human Genetics, University of Iowa Carver College of Medicine, Iowa City, IA, USA.ORCID 0000-0002-4433-9976
Tayyab RehmanDepartment of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, USA.ORCID 0000-0001-7792-201X
Henry L KeenIowa Institute of Human Genetics, University of Iowa Carver College of Medicine, Iowa City, IA, USA.ORCID 0009-0008-3548-7839
Philip H KarpDepartment of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, USA.ORCID 0009-0000-7642-1141
Eric B TaylorPappajohn Biomedical Institute, University of Iowa Carver College of Medicine, Iowa City, IA, USA.ORCID 0000-0003-4549-6567
Michael J WelshDepartment of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, USA.ORCID 0000-0002-1646-6206

Funding

Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Jong Sung Kim · 1990 to 2026
$40.5M
Respiratory virus infection in early cystic fibrosis lung diseaseP01HL091842 · NHLBI · UNIVERSITY OF IOWA · PI ZABNER, JOSEPH · 2008 to 2022
$34.2M
Pathology CoreP01HL152960 · NHLBI · UNIVERSITY OF IOWA · PI ENGELHARDT, JOHN F · 2020 to 2024
$11.6M
Regulation of Hepatic Macronutrient Metabolism by Mitochondrial Citrate TransportR01DK104998 · NIDDK · UNIVERSITY OF IOWA · PI TAYLOR, ERIC B · 2015 to 2022
$3.2M
Regulation of Hepatic Fuel Fluxes by the Mitochondrial Dicarboxylate CarrierR01DK138664 · NIDDK · UNIVERSITY OF IOWA · PI Eric B Taylor · 2024 to 2026
$1.5M
NHLBI NIH HHS P01 HL091842NHLBI NIH HHS P01 HL152960NIDDK NIH HHS R01 DK104998NIDDK NIH HHS R01 DK138664NIEHS NIH HHS P30 ES005605
6 · The paper itself

Abstract

Oxygen controls most metazoan metabolism, yet in mammals, tissue O

Indexed as

AirCell DifferentiationCitric AcidEpithelial CellsMitochondriaOxygenRespiratory MucosaCells, CulturedHumansHypoxia-Inducible Factor 1, alpha SubunitCitric AcidHypoxia-Inducible Factor 1, alpha SubunitOxygen

Identifiers

PMID39854459
PMCPMC11759043

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.