ArticlePloS one2025
The relationship between vitamin A and myopia: A population-based study.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- The Role of Vitamin D and Selected Nutrients in the Development of Myopia in Children and Young Adults: A Narrative Review.Journal of clinical medicine · 2026Review
- Childhood myopia in the modern environment: modifiable risk factors and evidence-based prevention.International journal of ophthalmology · 2026Review
- Vitamin A and Its Related Diseases.Food science & nutrition · 2025Review
- Causal relationship between multiple types of food intake and myopia: a Mendelian randomization study.International journal of ophthalmology · 2025Article
- Myopia development: multifactorial interplay, molecular mechanisms and possible strategies.Frontiers in medicine · 2025Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeWe sought to evaluate the relationship between blood vitamin A levels and myopia in adults aged ≥20 years in Korea.
methodsWe collected data of 15,899 participants aged ≥20 years from the Korean National Health and Nutrition Examination Survey. Participants underwent refraction tests to identify myopia and high myopia, and their blood pressure and obesity levels were measured. Blood tests were conducted to assess vitamin A, fasting blood glucose, triglyceride, and total cholesterol levels. Blood vitamin A levels were classified into quartiles.
resultsAfter adjusting for confounding variables like age, sex, income, education, hypertension, diabetes, and obesity, the odds ratio (OR) of blood vitamin A in the second quartile for myopia was 0.66, while the OR in the fourth quartile was 0.74 (P for trend < 0.001). Among women, the ORs for myopia in the second and third quartiles of blood vitamin A levels were 0.48 (95% confidence interval [CI], 0.35-0.66) and 0.67 (95% CI, 0.49-0.90), respectively (P for trend < 0.001). In men, the ORs for high myopia in the second, third, and fourth quartiles of blood vitamin A levels were 0.05 (95% CI, 0.004-0.58), 0.15 (95% CI, 0.024-0.91), and 0.05 (95% CI, 0.008-0.364), respectively (P for trend < 0.001).
conclusionAn inverse relationship was observed between higher blood vitamin A levels and the prevalence of myopia. Notably, higher blood vitamin A levels were associated with a lower prevalence of high myopia in men and a lower prevalence of myopia in women.
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