Evidence map›Paper›PMID 39854296›Full record

ArticlePloS one2025

Exploring effector protein dynamics and natural fungicidal potential in rice blast pathogen Magnaporthe oryzae.

Jannatul Ferdousy, Tanjin Barketullah Robin, Mst Sanjida Nasrin, Istiak Ahmed, Tawsif Hossain, Md Mehedi Hasan, Mehrab Hassan Soaeb, Md Ahsanul Tamim, Nusrat Jahan Yeasmin, Ummay Habiba and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Jannatul FerdousyPlant Breeding Division, Bangladesh Rice Research Institute, Gazipur, Bangladesh.
Tanjin Barketullah RobinFaculty of Biotechnology and Genetic Engineering, Sylhet Agricultural University, Sylhet, Bangladesh.
Mst Sanjida NasrinDepartment of Bioinformatics, School of Biosciences, University of Skövde, Skövde, Sweden.
Istiak AhmedDepartment of Pharmacy, Faculty of Science, East West University, Dhaka, Bangladesh.
Tawsif HossainDepartment of Microbiology, Primeasia University, Dhaka, Bangladesh.
Md Mehedi HasanDepartment of Biotechnology, Faculty of Agriculture, Bangladesh Agricultural University, Mymensingh, Bangladesh.
Mehrab Hassan SoaebDeparment of Agriculture, Faculty of Agriculture, Hajee Mohammad Danesh Science and Technology University, Dinajpur, Bangladesh.
Md Ahsanul TamimDepartment of Biotechnology, Faculty of Agriculture, Bangladesh Agricultural University, Mymensingh, Bangladesh.ORCID 0009-0003-8709-925X
Nusrat Jahan YeasminDepartment of Soil Science, Faculty of Agriculture, Bangladesh Agricultural University, Mymensingh, Bangladesh.ORCID 0009-0006-5984-7718
Ummay HabibaDepartment of Biotechnology, Faculty of Agriculture, Bangladesh Agricultural University, Mymensingh, Bangladesh.ORCID 0009-0004-3580-1251
Nadim AhmedFaculty of Biotechnology and Genetic Engineering, Sylhet Agricultural University, Sylhet, Bangladesh.
Nurul Amin RaniFaculty of Biotechnology and Genetic Engineering, Sylhet Agricultural University, Sylhet, Bangladesh.
Md Shishir BhuyianFaculty of Biotechnology and Genetic Engineering, Sylhet Agricultural University, Sylhet, Bangladesh.
Suvarna N VakareDepartment of Pharmaceutical Chemistry, Sinhgad Technical Education Society's, Sinhgad College of Pharmacy, Pune, Maharashtra, India.
Abu Tayab MoinDepartment of Genetic Engineering and Biotechnology, Faculty of Biological Sciences, University of Chittagong, Chattogram, Bangladesh.ORCID 0000-0002-2954-3215
Rajesh B PatilDepartment of Pharmaceutical Chemistry, Sinhgad Technical Education Society's, Sinhgad College of Pharmacy, Pune, Maharashtra, India.ORCID 0000-0003-2986-9546
Mohammad Shahadat HossainDepartment of Computer Science and Engineering, University of Chittagong, Chattogram, Bangladesh.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rice blast, caused by Magnaporthe oryzae, is one of the most destructive fungal diseases in rice, resulting in major economic losses worldwide. Genetic and genomic studies have identified key genes and proteins, such as AvrPik variants and MAX proteins, that are crucial for the pathogen's virulence. These effector proteins interact with specific alleles of the Pik gene family on rice chromosome 11, modulating the host's immune response. In this study, we investigated 35 plant-derived metabolites known for their antifungal properties as potential fungicides against M. oryzae. Using molecular docking, we identified Hecogenin and Cucurbitacin E as strong binders to MAX40 and APIKL2A proteins, which are essential for the fungus's immune evasion and pathogenicity. Molecular dynamics simulations further confirmed that these compounds form stable, strong interactions with the target proteins, validating their potential as therapeutic agents. Additionally, the compounds were evaluated based on Lipinski's rule of five and toxicity predictions, indicating their suitability for agricultural use. These results suggest that Hecogenin and Cucurbitacin E could serve as promising lead candidates in the development of novel fungicides for rice blast, offering new strategies for crop protection and sustainable agricultural practices.

Indexed as

AscomycotaFungal ProteinsFungicides, IndustrialMagnaportheOryzaPlant DiseasesMolecular Docking SimulationMolecular Dynamics SimulationFungal ProteinsFungicides, Industrial

Identifiers

PMID39854296
PMCPMC11761166

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.