Observational studyJournal of magnetic resonance imaging : JMRI2025
Reference Values for Water-Specific T1, Intermuscular and Intramuscular Fat Content in Skeletal Muscle at 2.89 T.
Observational study in Journal of magnetic resonance imaging : JMRI, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Quantification of skeletal muscle density, mass and fat fraction using single-energy computed tomography.Journal of orthopaedic translation · 2026Article
- Feasibility of tagged MRI at 0.55 T.Magnetic resonance in medicine · 2026Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMRI offers quantification of proton density fat fraction (PDFF) and tissue characteristics with T1 mapping. The influence of age, sex, and the potential confounding effects of fat on T1 values in skeletal muscle in healthy adults are insufficiently known. PURPOSE: To determine the accuracy and repeatability of a saturation-recovery chemical-shift encoded multiparametric approach (SR-CSE) for quantification of T1 STUDY TYPE: Prospective observational; phantoms (NiCL POPULATIONS: A total of 130 healthy community-dwelling adults (63 male, 18-76 years) free of chronic health conditions that require regular prescription medication, and with no contraindications to MRI. FIELD STRENGTH/SEQUENCE: 2.89 T; gradient echo sequences including saturation-recovery chemical-shift encoded T1 mapping (SR-CSE); MOLLI; SASHA; CSE; and single voxel spectroscopy. ASSESSMENT: SR-CSE provided T1 STATISTICAL TESTS: Univariable and multivariable linear regression, general linear models, Bland and Altman, coefficient of variation (CV). P-value <0.05 was considered statistically significant.
resultsPhantom and in vivo validation studies showed excellent accuracy of SR-CSE T1 DATA
conclusionSR-CSE provides accurate (vs. phantoms) and repeatable assessment of water-specific T1 values and muscle and fat volumes. Conventional methods (SASHA, MOLLI) have a significant fat-modulated T1-bias. T1 PLAIN LANGUAGE SUMMARY: We developed and tested the accuracy of a new MRI approach to measure tissue damage in skeletal muscle using a method called T1 mapping. The approach also provided matching images of fat within the muscle. We measured T1 values and muscle fat volumes in the thighs of 130 healthy adults to define normal values in healthy people and to understand if these values are influenced by age, sex, or weight. We found that our MRI technique accurately measured T1 values and fat volumes within muscle and we defined normal ranges of values, which were different in healthy males and females. LEVEL OF EVIDENCE: 2 TECHNICAL EFFICACY: Stage 1.
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