Evidence map›Paper›PMID 39854216›Full record

ReviewDiabetes2025

Homeobox C4 Transcription Factor Promotes Adipose Tissue Thermogenesis.

Ting Yang, Yuxuan Wang, Hang Li, Fengshou Shi, Siqi Xu, Yingting Wu, Jiaqi Xin, Yi Liu, Mengxi Jiang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Diabetes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ting YangDepartment of Pharmacology, School of Basic Medical Sciences, Capital Medical University, Beijing, China.
Yuxuan WangSchool of Traditional Chinese Medicine, Capital Medical University, Beijing, China.
Hang LiSchool of Traditional Chinese Medicine, Capital Medical University, Beijing, China.
Fengshou ShiDepartment of Pharmacology, School of Basic Medical Sciences, Capital Medical University, Beijing, China.
Siqi XuDepartment of Pharmacology, School of Basic Medical Sciences, Capital Medical University, Beijing, China.
Yingting WuSchool of Pharmacy, Capital Medical University, Beijing, China.
Jiaqi XinDepartment of Pharmacology, School of Basic Medical Sciences, Capital Medical University, Beijing, China.
Yi LiuDepartment of Pharmacology, School of Basic Medical Sciences, Capital Medical University, Beijing, China.
Mengxi JiangDepartment of Pharmacology, School of Basic Medical Sciences, Capital Medical University, Beijing, China.ORCID 0000-0003-4446-984X

Funding

National Natural Science Foundation of China 82270898Youth Talent Training Program of Capital Medical University
6 · The paper itself

Abstract

article highlightsHomeobox C4 (HOXC4) links metabolic pathways and correlates inversely with mouse body weight and positively with Ucp1 expression in mouse adipose tissue. Gain- and loss-of-function experiments in mice demonstrated HOXC4's essential role in promoting adipose thermogenesis and providing metabolic benefits. HOXC4 interacts with the nuclear receptor coactivator 1 cofactor via its hexapeptide motif to activate Ucp1 transcription, revealing a novel mechanism of thermogenic gene regulation.

Indexed as

Adipose TissueHomeodomain ProteinsThermogenesisTranscription FactorsAdipose Tissue, BrownAnimalsGene Expression RegulationHumansMiceUncoupling Protein 1Homeodomain ProteinsTranscription FactorsUcp1 protein, mouseUncoupling Protein 1

Identifiers

PMID39854216
PMCPMC11926272

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.