ArticleTranslational vision science & technology2025
Determinants of Human Corneal Mechanical Wave Dispersion for In Vivo Optical Coherence Elastography.
Article in Translational vision science & technology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Super-resolution wave-dispersion analysis in optical coherence elastography using multiple signal classification (MUSIC).Biomedical optics express · 2026Article
- Phantoms for use in optical coherence elastography.Journal of biomedical optics · 2026Review
- Air-Coupled Ultrasonic Optical Coherence Elastography Reveals Protocol-Dependent Corneal Stiffening in Epi-On and Epi-Off Riboflavin Crosslinking.Translational vision science & technology · 2026Article
- Wavelet time-frequency analysis enhances noise-resilient quantification of corneal wave velocity and natural frequency in optical coherence elastography.Biomedical optics express · 2026Article
- Air-pulse optical coherence elastography: how excitation angle affects mechanical wave propagation.Biomedical optics express · 2025Article
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Authors and funding
6 authors.
Funding
Abstract
Purpose: To characterize frequency-dependent wave speed dispersion in the human cornea using microliter air-pulse optical coherence elastography (OCE), and to evaluate the applicability of Lamb wave theory for determining corneal elastic modulus using high-frequency symmetric (S0) and anti-symmetric (A0) guided waves in cornea. Methods: Wave speed dispersion analysis for transient (0.5 ms) microliter air-pulse stimulation was performed in four rabbit eyes ex vivo and compared to air-coupled ultrasound excitation. The effects of stimulation angle and sample geometry on the dispersion were evaluated in corneal phantoms. Corneal wave speed dispersion was measured in 36 healthy human eyes in vivo. Results: Air-pulse-induced dispersion was comparable to ultrasound-induced dispersion between 0.7 and 5 kHz (mean-difference ± 1.96 × SD: 0.006 ± 0.5 m/s) in ex vivo rabbit corneas. Stimulation 0° relative to the surface normal generated A0 Lamb waves in corneal tissue phantoms, while oblique stimulation (35° and 65°) generated S0 waves. Stimulating normal to the human corneal apex in vivo (0°) induced A0 waves, plateauing at 10.87 to 13.63 m/s at 4 kHz, and when obliquely stimulated at the periphery (65°), produced S0 waves, plateauing at 13.10 to 15.98 m/s at 4 kHz. Conclusions: Air-pulse OCE can be used to measure human corneal Lamb wave dispersion of A0 and S0 propagation modes in vivo. These modes are selectively excited by changing the stimulation angle. Accounting for wave speed dispersion enables reliable estimation of corneal elastic modulus in vivo. Translational Relevance: This work demonstrates the feasibility of air-pulse stimulation for robust OCE measurements of corneal stiffness in vivo for disease detection and therapy evaluation.
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