Evidence map›Paper›PMID 39854068›Full record

Trial reportAnaesthesia2025

Incidence of 12-month postoperative cognitive decline following regional vs. general anaesthesia in older patients undergoing hip fracture surgery: follow-up of the RAGA trial.

Ting Li, Jun Li, Chenchen Jiang, Liyong Yuan, Jinze Wu, Ali Mazaheri, Mingcang Wang, Shengwei Jin, Paul S Myles, Yinguang Yao and 4 more

Erratum issuedAbstract readMulticenter StudyRandomized Controlled TrialComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Anaesthesia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Ting LiDepartment of Anaesthesiology and Perioperative Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Jun LiDepartment of Anaesthesiology and Perioperative Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Chenchen JiangClinical Research Unit, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Liyong YuanDepartment of Anaesthesiology and Perioperative Medicine, Ningbo No.6 Hospital, Ningbo, China.
Jinze WuDepartment of Anaesthesiology and Perioperative Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Ali MazaheriSchool of Psychology, University of Birmingham and Centre for Human Brain Health, University of Birmingham, Birmingham, UK.
Mingcang WangDepartment of Anaesthesiology and Perioperative Medicine, Taizhou Hospital of Zhejiang Province, Taizhou, China.
Shengwei JinDepartment of Anaesthesiology and Perioperative Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Paul S MylesDepartment of Anaesthesiology and Perioperative Medicine, Alfred Hospital and Monash University, Melbourne, Australia.
Yinguang YaoDepartment of Anaesthesiology and Perioperative Medicine, Lishui Municipal Central Hospital, Lishui, China.
Jimin WuDepartment of Anaesthesiology and Perioperative Medicine, Lishui People's Hospital, Lishui, China.
Junping ChenDepartment of Anaesthesiology and Perioperative Medicine, Hwa Mei Hospital, University of Chinese Academy of Sciences, Ningbo No.2 Hospital, Ningbo, China.
Fang G SmithClinical Research Unit, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
RAGA study investigators

Funding

Clinical Research Foundation of the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University SAHoWMU-CR2017-03-110Natural Science Foundation of China 82271225NIHR Senior Investigator AwardZhejiang Province Basic Public Welfare Research Project LGF21H250004
6 · The paper itself

Abstract

introductionData regarding the incidence of 12-month postoperative cognitive decline following regional or general anaesthesia in older patients undergoing hip fracture surgery remain observational. Compared with general anaesthesia, we hypothesised that regional anaesthesia would decrease the incidence of 12-month postoperative cognitive decline.

methodsThis is substudy of a multicentre randomised trial of regional anaesthesia with no sedation vs. general anaesthesia with 12-month follow-up, conducted in nine university hospitals in south-eastern China. Patients aged ≥ 65 y with hip fractures requiring surgery were eligible for inclusion. The prespecified 1-year primary outcome was the incidence of postoperative cognitive decline at 12 months post-randomisation. Secondary outcomes included major or mild postoperative cognitive decline; changes in Mini-Mental State Examination; newly developed dementia; affective status; and health-related quality of life.

resultsWe recruited 950 patients between October 2014 and September 2018 (n = 474 general and n = 476 regional), with the last participant interviewed in November 2019. A total of 293 patients (139 general vs. 154 regional) were included in the primary analysis of the 12-month outcome. Median (IQR [range]) age of patients was 78 (71-82 [65-96]) y and 217 (74.1%) were female. The incidence of cognitive decline at 12 months was 29.7% vs. 25.4% of patients allocated to general vs. regional anaesthesia, respectively (unadjusted OR 1.2 (95%CI 0.7-2.1), p = 0.43, Bayes factor = 0.28). Major cognitive decline developed in 8.6% vs. 8.5% of patients allocated to general vs. regional anaesthesia, respectively (unadjusted OR 1.0 (95%CI 0.4-2.4)). DISCUSSION: The incidence of 12-month postoperative cognitive decline was not significantly different in patients having general or regional anaesthesia for hip fracture surgery.

Indexed as

Anesthesia, ConductionAnesthesia, GeneralCognitive DysfunctionHip FracturesPostoperative Cognitive ComplicationsPostoperative ComplicationsAgedAged, 80 and overChinaFemaleFollow-Up StudiesHumansIncidenceMalegeneral anaesthesiahip fractureneurocognitive functionolder patientsregional anaesthesia

Identifiers

PMID39854068
PMCPMC12171792

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.