ArticleInvestigative ophthalmology & visual science2025
Preferential Sites of Retinal Capillary Occlusion in Sickle Cell Disease.
Article in Investigative ophthalmology & visual science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Retinal imaging and supervised learning predict hospitalizations and kidney and heart-lung damage in sickle cell disease.Blood advances · 2026Observational
- Microvascular Volume Loss Exceeds Nerve Fiber Layer but Not Neuroretinal Rim Tissue Loss During Progression of Nonhuman Primate Experimental Glaucoma.Investigative ophthalmology & visual science · 2026Article
- Assessing the Relationship between Foveal Cone Density, Outer Nuclear Layer Thickness and Foveal Morphology.Ophthalmology science · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Purpose: To assess the preferential sites of retinal capillary occlusion at the parafovea in patients with sickle cell disease (SCD) using optical coherence tomography angiography (OCT-A). Methods: OCT-A scans from 107 patients with SCD and 51 race-matched unaffected controls were obtained using a commercial spectral domain-OCT system. At least eight sequential 3 × 3 mm scans centered at the fovea were acquired and averaged for image analysis. In each participant, foveal avascular zone (FAZ) metrics, perivascular, and quadrant-based capillary densities were measured on the averaged full vascular retinal OCT-A slab. Intermittent capillary perfusion at the FAZ border was also identified using sequential registered OCT-A scans. Results: Perivascular and quadrant-based capillary densities were significantly lower in SCD groups (Kruskal-Wallis tests; P < 0.001) with preferential sites of capillary nonperfusion occurring along periarteriolar aspect of the vascular bed and at the temporal aspect of the fovea. FAZ perimeter and acircularity index were significantly higher in SCD groups (Kruskal-Wallis tests; P ≤ 0.05). However, no significant differences in FAZ area between unaffected control and SCD groups were observed (Kruskal-Wallis test; P = 0.08). The number of capillary segments with intermittent perfusion was higher in the SCD groups. Conclusions: Our findings suggest that the periarteriolar aspect of the vascular bed is the preferential site of retinal capillary occlusion in patients with SCD with more involvement of the temporal aspect of the parafovea.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.