ArticleVeterinary medicine and science2025
Comprehensive Evaluation of Changes in Placentomes in the Second and Third Trimesters of Pregnancy in Cross-Bred Hamdani Sheep.
Article in Veterinary medicine and science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Protective effect of dietary L-carnitine supplementation on follicular development in the ovary of ewes with subclinical pregnancy toxemia.Archives animal breeding · 2026Article
- Association of DGAT1 and POU1F1 Gene Polymorphisms With the Milk Traits in the Cross-Bred Hamdani Sheep Bred Under Extensive Management.Veterinary medicine and science · 2025Article
- Sexual Dimorphism of Foetal Sheep Skulls During the Second and Third Periods of Pregnancy.Veterinary medicine and science · 2025Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA proper placentation is required for establishment and continuity of pregnancy. In sheep, placentomes are unique structures that enable nutrition and gas exchange between the mother and the foetus. Although placentomes are dynamic formations, there is limited knowledge of changes in placentomes during pregnancy.
objectiveThis study aimed to identify changes in sheep placentomes in the second and third trimesters of pregnancy using both macroscopic and microscopic methods.
methodsThis study investigated 14 healthy cross-breed Hamdani sheep placentomes, comprising seven second and seven third trimesters of pregnancy. The histomorphometric analysis included measurements of capillary number and area in cotyledonary and caruncular regions, while morphometric assessments encompassed placentome dimensions such as number, length, width, and depth.
resultsPlacentomes were oval and circular in shape in the second and third trimesters. In the second trimester, they were observed as concave structures with thick edges, whereas in the third trimester, they were determined as thin-edged structures with a slight depression in the centre. In the third trimester, foetal and maternal tissues became more intertwined with increased branching of foetal villi and maternal crypts. Placental hematomas and erythrocytes in the cytoplasm of trophoblast cells were more prominent in the third trimester. Statistical analysis revealed no difference in placentome number between the second and third trimesters. However, the dimensions (length, width, and depth) of placentomes were greater in the third trimester compared to the second trimester (p < 0.001). Additionally, while there was no difference in the number of cotyledonary versus caruncular capillaries in the second trimester, cotyledonary capillaries outnumbered caruncular capillaries in the third trimester (p < 0.001). Furthermore, both cotyledonary and caruncular capillary areas increased in the third trimester compared to the second trimester, with the caruncular capillary area being consistently higher than the cotyledonary capillary area in both trimesters (p < 0.05).
conclusionThis study underscores the substantial structural and physiological transformations of placentomes in the second and third trimesters of pregnancy in sheep. These adaptations facilitate efficient flow exchange between the foetus and mother, highlighting the dynamic nature of placental development during late gestation.
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