ArticleJournal of veterinary internal medicine
Characterization and comparison of fecal microbiota in horses with pituitary pars intermedia dysfunction and age-matched controls.
Article in Journal of veterinary internal medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- A Comprehensive Review of the Equine Gut Microbiome in Health and Disease.Veterinary sciences · 2026Review
- Characterization and comparison of fecal microbiota in horses with pituitary pars intermedia dysfunction and age-matched controls.Journal of veterinary internal medicineArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundAltered gut microbiota has been associated with dopaminergic degenerative diseases in people, but studies on horses with pituitary pars intermedia dysfunction (PPID) are lacking. HYPOTHESIS/
objectivesInvestigate the effect of PPID on fecal microbiota in horses. ANIMALS: Nine horses with PPID and 13 age-matched control horses.
methodsProspective control study. Fecal samples were collected bimonthly. Microbial analysis used 16S rRNA sequencing to determine the relative abundance at genus and phylum levels, assess alpha and beta diversity and identify core microbiota.
resultsHorses with PPID had decreased relative abundances of Christensenellaceae R-7 group (median; 95% confidence interval [CI]: PPID, 2.04; 1.82-2.35 vs control, 2.54; 2.37-2.76; P = .02) and NK4A214 group (PPID, 2.21; 2.02-2.56 vs control, 2.62; 2.44-2.85; P = .05), and significant lower abundances of Romboutsia (log2FoldChange = -3.54; P = .04) and Peptococcaceae uncultured (log2FoldChange = -0.89; P = .04) by differential abundance analysis. However, the abundance of Fibrobacter (log2FoldChange = 0.74; P = .04) was significantly higher in the PPID group. A significant effect of PPID on beta diversity was observed (P = .004), whereas alpha diversity varied with months (P = .001). Seven unique genera were identified in horses with PPID and 12 in control horses. CONCLUSIONS AND CLINICAL IMPORTANCE: The fecal microbial composition is altered in horses with PPID. These findings support the potential role of the microbiota-gut-brain axis in the pathogenesis of PPID.
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Registered trials
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