Evidence map›Paper›PMID 39853796›Full record

ArticleStatistics in medicine2025

Non-Parametric Estimation for Semi-Competing Risks Data With Event Misascertainment.

Ruiqian Wu, Ying Zhang, Giorgos Bakoyannis

Abstract read
In one paragraph

Article in Statistics in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ruiqian WuDepartment of Biostatistics, University of Nebraska Medical Center, Omaha, NE.
Ying ZhangDepartment of Biostatistics, University of Nebraska Medical Center, Omaha, NE.ORCID 0000-0002-9680-8981
Giorgos BakoyannisDepartment of Biostatistics and Health Data Science, Indiana University, Indianapolis, IN.ORCID 0000-0002-2789-2497

Funding

East Africa International Epidemiology Database to evaluate AIDS (IeDEA) Regional ConsortiumU01AI069911 · NIAID · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI AGGREY SEMWENDERO SEMEERE, Kara Kay Wools-Kaloustian · 2006 to 2026
$57.7M
Tracking and Evaluation CoreU54GM115458 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI GUDA, CHITTIBABU · 2016 to 2025
$42.8M
PREDICTIONS OF DRIVER SAFETY IN ADVANCING AGER01AG017177 · NIA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI RIZZO, MATTHEW · 1999 to 2024
$9.9M
National Institute of Aging R01AG017177NIAID NIH HHS U01 AI069911NIA NIH HHS R01 AG017177NIGMS NIH HHS U54 GM115458NIGMS NIH HHS U54GM115458
6 · The paper itself

Abstract

The semi-competing risks data model is a special type of disease-state model that focuses on studying the association between an intermediate event and a terminal event and proves to be a useful tool in modeling disease progression. The study of the semi-competing risk data model not only allows us to evaluate whether a disease episode is related to death but also provides a toolkit to predict death, given that the episode occurred at a certain time. However, the computation of the semi-competing risk models is a numerically challenging task. The Gamma-Frailty conditional Markov model has been shown to be an efficient computation model for studying semi-competing risks data. Building on recent advances in studying semi-competing risks data, this work proposes a non-parametric pseudo-likelihood method equipped with an EM-like algorithm to study semi-competing risks data with event misascertainment under the restricted Gamma-Frailty conditional Markov model. A thorough simulation study is conducted to demonstrate the inference validity of the proposed method and its numerical stability. The proposed method is applied to a large HIV cohort study, EA-IeDEA, that has a severe death under-reporting issue to assess the degree of adverse impact of the interruption of ART care on HIV mortality.

Indexed as

Models, StatisticalAlgorithmsCohort StudiesComputer SimulationDisease ProgressionHIV InfectionsHumansLikelihood FunctionsMarkov ChainsRisk AssessmentStatistics, NonparametricEM algorithmillness‐death modelmissing cause of failurenon‐parametric pseudo‐likelihood estimationsemi‐competing risks

Identifiers

PMID39853796
PMCPMC11758483

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.