Evidence map›Paper›PMID 39853757›Full record

ArticleEuropean journal of immunology2025

The Anti-Human P2X7 Monoclonal Antibody (Clone L4) Can Mediate Complement-Dependent Cytotoxicity of Human Leukocytes.

Amal Elhage, Debbie Watson, Ronald Sluyter

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Amal ElhageMolecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, Australia.ORCID 0000-0003-0625-3183
Debbie WatsonMolecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, Australia.ORCID 0000-0002-6242-3944
Ronald SluyterMolecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, Australia.ORCID 0000-0003-4909-686X

Funding

Australian Government Research Training ProgrammeUniversity of Wollongong Near Miss GrantUniversity of Wollongong RevITAlise T021
6 · The paper itself

Abstract

P2X7 is an extracellular adenosine 5'-triphosphate (ATP)-gated cation channel that plays various roles in inflammation and immunity. P2X7 is present on peripheral blood monocytes, dendritic cells (DCs), and innate and adaptive lymphocytes. The anti-human P2X7 monoclonal antibody (mAb; clone L4), used for immunolabelling P2X7 or blocking P2X7 activity, is a murine IgG2

Indexed as

Antibodies, MonoclonalComplement System ProteinsCytotoxicity, ImmunologicLeukocytesReceptors, Purinergic P2X7Adenosine TriphosphateAnimalsHEK293 CellsHumansMiceMonocytesAdenosine TriphosphateAntibodies, MonoclonalComplement System ProteinsP2RX7 protein, humanReceptors, Purinergic P2X7complement‐dependent cytotoxicityP2RX7P2X7P2X7 expressionpurinergic receptorpurinergic signallingtherapeutic antibody

Identifiers

PMID39853757
PMCPMC11760643

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.