Evidence map›Paper›PMID 39853574›Full record

Observational studyJapanese journal of ophthalmology2025

Surgical outcomes after trabeculotomy for primary congenital glaucoma.

Ayaka Edo, Kazuyuki Hirooka, Hideaki Okumichi, Asayo Yoshinaka, Shintaro Kohno, Yoshiaki Kiuchi

Registry-linked trialAbstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Japanese journal of ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07550868 (Efficacy and Safety of Different Extents of Goniotomy in Primary Congenital Glaucoma), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07550868 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Efficacy and Safety of Different Extents of Goniotomy in Primary Congenital Glaucoma

TypeobservationalSponsorSun Yat-sen UniversityRan2026 to 2029Enrolled120ConditionsPrimary Congenital Glaucoma, Goniotomy
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ayaka EdoDepartment of Ophthalmology and Visual Science, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan. ayakae@hiroshima-u.ac.jp.ORCID http://orcid.org/0000-0001-7701-605X
Kazuyuki HirookaDepartment of Ophthalmology and Visual Science, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Hideaki OkumichiDepartment of Ophthalmology and Visual Science, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Asayo YoshinakaDepartment of Ophthalmology and Visual Science, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Shintaro KohnoDepartment of Ophthalmology, Tsukazaki Hospital, Himeji, Japan.
Yoshiaki KiuchiDepartment of Ophthalmology and Visual Science, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.

Funding

Alcon Japan Alcon Japan
6 · The paper itself

Abstract

purposeTo investigate outcomes after trabeculotomy in Japanese patients with primary congenital glaucoma (PCG), and to identify risk factors for multiple glaucoma surgery procedures. STUDY

designRetrospective observational study.

methodsSurgical outcomes were investigated in Japanese patients with PCG who underwent their first glaucoma surgery at Hiroshima University Hospital between January, 2006, and December, 2021. The data included in this study were divided into single- and multiple-surgery groups, and risk factors for requiring multiple surgery procedures were evaluated using multivariate analysis.

resultsTwenty eyes of 20 patients were included. All eyes underwent ab externo trabeculotomy as the first surgery. The mean follow-up period was 75.7 ± 44.8 months. The cumulative success rate for up to 3 trabeculotomies at 5 years after the first surgery was 89.7%. The glaucoma in 11 eyes (55.0%) was controllable with just one surgery, whereas 9 eyes (45.0%) required 2 or more glaucoma surgical procedures. The single-surgery group had a significantly better mean best-corrected visual acuity at the last visit than the multiple-surgery group (0.1 ± 0.1 versus 0.9 ± 1.1, respectively, p = 0.001) and a smaller mean cylindrical power (- 0.8 ± 0.8 versus - 2.2 ± 1.0, respectively, p = 0.01). In multivariate logistic analysis, a 1-mm increase in corneal diameter was associated with a 16-fold increase in the risk of multiple glaucoma surgical procedures (p = 0.047).

conclusionThe glaucoma in most PCG eyes can be controlled with up to three trabeculotomies. Corneal-diameter enlargement was a significant risk factor for multiple surgical procedures.

Indexed as

GlaucomaHydrophthalmosIntraocular PressureTrabeculectomyVisual AcuityChildChild, PreschoolFemaleFollow-Up StudiesHumansInfantMaleRetrospective StudiesRisk FactorsTreatment OutcomeChildhood glaucomaMultiple operationsPrimary congenital glaucomaSurgical outcomeTrabeculotomy

Identifiers

PMID39853574

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.