Evidence map›Paper›PMID 39853538›Full record

ArticleParasitology research2025

Immunomodulatory activity of Trypanosoma cruzi recombinant antigen combination TSA-1-C4 and Tc24-C4 induce activation of macrophages and CD8

Victor Manuel Dzul-Huchim, Miguel Rosado-Vallado, Antonio Euan-Canto, Julio Torres-Romero, Jaime Ortega-Lopez, Julio Vladimir Cruz-Chan, Liliana Estefania Villanueva-Lizama, Victor Arana-Argáez

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Parasitology research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Vaccines against chronicExpert review of vaccines · 2026
    Review
  2. Review
  3. Review
  4. Chagas disease: host responses, parasite evasion and vaccine advances.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2026
    Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Victor Manuel Dzul-HuchimCentro de Investigaciones Regionales (C.I.R.) Dr. Hideyo Noguchi, Universidad Autónoma de Yucatán (UADY), Calle 43 S/N entre calle 96 y calle 40 Colonia Inalámbrica, Mérida, Yucatán, C.P. 97069, Mexico.
Miguel Rosado-ValladoCentro de Investigaciones Regionales (C.I.R.) Dr. Hideyo Noguchi, Universidad Autónoma de Yucatán (UADY), Calle 43 S/N entre calle 96 y calle 40 Colonia Inalámbrica, Mérida, Yucatán, C.P. 97069, Mexico.
Antonio Euan-CantoFacultad de Química, Universidad Autónoma de Yucatán (UADY), Calle 43 S/N entre calle 96 y calle 40 Colonia Inalámbrica, Mérida, Yucatán, C.P. 97069, Mexico.
Julio Torres-RomeroFacultad de Química, Universidad Autónoma de Yucatán (UADY), Calle 43 S/N entre calle 96 y calle 40 Colonia Inalámbrica, Mérida, Yucatán, C.P. 97069, Mexico.
Jaime Ortega-LopezCentro de Investigación y Estudios Avanzados (CINVESTAV), del Instituto Politécnico Nacional (I.P.N.), San Pedro Zacatenco Gustavo A. Madero, Ciudad de México, C.P. 07360, Mexico.
Julio Vladimir Cruz-ChanCentro de Investigaciones Regionales (C.I.R.) Dr. Hideyo Noguchi, Universidad Autónoma de Yucatán (UADY), Calle 43 S/N entre calle 96 y calle 40 Colonia Inalámbrica, Mérida, Yucatán, C.P. 97069, Mexico.
Liliana Estefania Villanueva-LizamaCentro de Investigaciones Regionales (C.I.R.) Dr. Hideyo Noguchi, Universidad Autónoma de Yucatán (UADY), Calle 43 S/N entre calle 96 y calle 40 Colonia Inalámbrica, Mérida, Yucatán, C.P. 97069, Mexico.
Victor Arana-ArgáezFacultad de Química, Universidad Autónoma de Yucatán (UADY), Calle 43 S/N entre calle 96 y calle 40 Colonia Inalámbrica, Mérida, Yucatán, C.P. 97069, Mexico. victor.arana@correo.uady.mx.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chagas disease is a chronic infection caused by the protozoan parasite, Trypanosoma cruzi, with limited benefits of the currently available anti-parasitic chemotherapeutic approaches to halt the progression of heart disease. Recombinant TSA-1-C4 and Tc24-C4 proteins have been developed as promising antigen candidates for therapeutic vaccines, leading to propose them in combination as a bivalent recombinant protein strategy. In this study, we evaluated the immunomodulatory effect of the combined TSA-1-C4 and Tc24-C4 recombinant proteins by in vitro assays using murine macrophages. Macrophages from naïve Balb/c mice were isolated and stimulated with TSA-1-C4 plus Tc24-C4 recombinant proteins, hence, supernatants were recovered to measure host NO, H

Indexed as

Antigens, ProtozoanMacrophage ActivationProtozoan VaccinesTrypanosoma cruziAnimalsCD8-Positive T-LymphocytesChagas DiseaseFemaleInflammationMacrophages, PeritonealMaleMiceMice, Inbred BALB CAntigens, ProtozoanProtozoan VaccinesCD8+ T cellChagas diseaseImmunomodulatoryMacrophagesTc24-C4Trypanosoma cruziTSA-1-C4

Identifiers

PMID39853538
PMCPMC11761814

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.