Evidence map›Paper›PMID 39853513›Full record

ArticleActa parasitologica2025

Laminated Layer Extract from Echinococcus Granulosus cyst Attenuates Ocular Damages and Inflammatory Responses in an Experimental Autoimmune Uveitis Model.

Sara Djebbara, Houda Belguendouz, Imene Soufli, Leila Hannachi, Fahima Ameur, Sara Benazzouz, Sarra Benkhelifa, Malika Terrahi, Karima Achour, Zine-Charaf Amir and 2 more

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In one paragraph

Article in Acta parasitologica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Sara DjebbaraCytokines and NO Synthases Team, LBCM, FSB, USTHB, BP 32 El Alia, Bab Ezzouar, Algiers, 16111, Algeria.
Houda BelguendouzCytokines and NO Synthases Team, LBCM, FSB, USTHB, BP 32 El Alia, Bab Ezzouar, Algiers, 16111, Algeria.ORCID http://orcid.org/0000-0003-3641-4291
Imene SoufliCytokines and NO Synthases Team, LBCM, FSB, USTHB, BP 32 El Alia, Bab Ezzouar, Algiers, 16111, Algeria.
Leila HannachiDepartment of Pathological Anatomy, University Hospital Center Mustapha Pacha, Algiers, Algeria.
Fahima AmeurCytokines and NO Synthases Team, LBCM, FSB, USTHB, BP 32 El Alia, Bab Ezzouar, Algiers, 16111, Algeria.
Sara BenazzouzInstitute of Parasitology, Vetsuisse Faculty, University of Bern, Länggassstrasse 122, CH-3012, Bern, Switzerland.ORCID http://orcid.org/0000-0002-6519-2061
Sarra BenkhelifaCytokines and NO Synthases Team, LBCM, FSB, USTHB, BP 32 El Alia, Bab Ezzouar, Algiers, 16111, Algeria.
Malika TerrahiDepartment of Ophthalmology, University Hospital Center Nafissa Hammoud, Algiers, Algeria.
Karima AchourThoracic Surgery Department, University Hospital Center Bab El Oued, Algiers, Algeria.ORCID http://orcid.org/0000-0002-2680-0247
Zine-Charaf AmirDepartment of Pathological Anatomy, University Hospital Center Mustapha Pacha, Algiers, Algeria.ORCID http://orcid.org/0000-0002-2238-2113
Manel AmriCytokines and NO Synthases Team, LBCM, FSB, USTHB, BP 32 El Alia, Bab Ezzouar, Algiers, 16111, Algeria.ORCID http://orcid.org/0000-0003-4185-163X
Chafia Touil-BoukoffaCytokines and NO Synthases Team, LBCM, FSB, USTHB, BP 32 El Alia, Bab Ezzouar, Algiers, 16111, Algeria. touilboukoffa@yahoo.fr.ORCID http://orcid.org/0000-0001-7728-2147

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeSince extract of the laminated layer (LL) from E. granulosus showed immuno-modulatory effects in vitro and in vivo, we sought to determine its effect on the onset, development, and evolution of experimental auto-immune uveitis (EAU). The latter is a model of some human diseases with ocular inflammation that can cause blindness.

methodsE. granulosus LL extract was either injected before EAU induction for the pretreated group or later for treated group. Ocular exploration was made by retinal histological and immunohistological (CD86, CD4, CD8) analysis. Myeloperoxidase (MPO), Superoxide dismutase (SOD), Catalase enzymatic activities (CAT), and Malondialdehyde (MDA), Nitric oxide (NO), Urea, and TNF-α levels were measured in plasma.

resultsLL injection attenuated retinal histological damage and reduced cells infiltration. Also, LL decreased systemic inflammatory and oxidative markers as well as TNF-α production and increased antioxidant parameters.

conclusionsInterestingly, we observed a protective effect of E. granulosus LL extract during EAU. LL appears to ameliorate retinal damage by down-regulating inflammatory responses. Our results support LL immunomodulatory effects during autoimmune diseases and offer a promising prospect for helminthic therapy during autoimmune uveitis.

Indexed as

Autoimmune DiseasesEchinococcus granulosusUveitisAnimalsDisease Models, AnimalFemaleRetinaAnti-inflammatory effectEchinococcus granulosusExperimental auto-immune UveitisImmunomodulationLaminated layerProtective effect

Identifiers

PMID39853513

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.