Evidence map›Paper›PMID 39853408›Full record

ArticleArchives of microbiology2025

Exposure to spaceflight enhances the virulence of Purpureocillium lilacinum against Tetranychus cinnabarinus: modulation of the host's enzyme activities and microbiome.

Xiaoxiao Wang, Fangzhao Yi, Chengli Zou, Qi Yan, Muhammad Hamid Bashir, Waqar Ahmed, Syed Usman Mahmood, Jianhui Wu, Shaukat Ali

Abstract read
PubMed Publisher
In one paragraph

Article in Archives of microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Oral Exposure toInsects · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xiaoxiao WangEngineering Research Center of Biological Control, Ministry of Education and Guangdong Province, South China Agricultural University, Guangzhou, 510642, China.
Fangzhao YiEngineering Research Center of Biological Control, Ministry of Education and Guangdong Province, South China Agricultural University, Guangzhou, 510642, China.
Chengli ZouEngineering Research Center of Biological Control, Ministry of Education and Guangdong Province, South China Agricultural University, Guangzhou, 510642, China.
Qi YanEngineering Research Center of Biological Control, Ministry of Education and Guangdong Province, South China Agricultural University, Guangzhou, 510642, China.
Muhammad Hamid BashirDepartment of Entomology, University of Agriculture, Faisalabad, Pakistan.
Waqar AhmedProvince Key Laboratory of Microbial Signals and Disease Control, College of Plant Protection, South China Agricultural University, Guangzhou, 510642, China.
Syed Usman MahmoodGuangdong Key Laboratory of Animal Conservation and Resource Utilization, Institute of Zoology, Guangdong Academy of Sciences, Guangzhou, 510260, Guangdong, China.
Jianhui WuEngineering Research Center of Biological Control, Ministry of Education and Guangdong Province, South China Agricultural University, Guangzhou, 510642, China. jhw@scau.edu.cn.
Shaukat AliEngineering Research Center of Biological Control, Ministry of Education and Guangdong Province, South China Agricultural University, Guangzhou, 510642, China. aliscau@scau.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiple studies have been conducted to investigate the impact of space conditions on human, plant, and microbial life. This research investigated the virulence of spaceflight mutants of the entomopathogenic fungus Purpureocillium lilacinum (HP7, HP36, HP52) and its original strain (SP535) against Tetranychus cinnabarinus as well as examination of the T. cinnabarinus immune response, including alterations in enzyme profiles and microbiome composition post fungal application. Our observations revealed contrasting, time-specific differences in pathogenicity and tissue infection between the ground-based isolate and spaceflight mutant isolates. Analysis of detoxifying and antioxidant enzymes showed a significant reduction in enzyme activities T. cinnabarinus infected with the most virulent spaceflight mutants at 36 h post-fungal infection, compared to ground-based isolates. Additionally, the microbiota was reduced due to a fungal infection, partly due to decreased antioxidant enzyme activities. Our findings indicate that changes in the microbiota of T. cinnabarinus following infection with P. lilacinum (both ground-based and spaceflight mutant isolates) resulted in variations in metabolism and genetic information-related KEGG pathways. This data can help identify potential changes in the host immune system that drive increased virulence after spaceflight mutation.

Indexed as

HypocrealesMicrobiotaTetranychidaeAnimalsVirulenceDetoxifying and antioxidant enzymesEntomopathogenic fungiLeaf mitesMicrobiomeSpace mutationVirulence

Identifiers

PMID39853408

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.