Evidence map›Paper›PMID 39853260›Full record

ArticleJournal of gynecologic oncology2025

Fertility-sparing treatment outcomes using immune checkpoint inhibitors in endometrial cancer patients with Lynch syndrome.

Xintong Yang, Yu Xue, Wenyu Shao, Weiwei Shan, Zhiying Xu, Yiqin Wang, Xiaojun Chen

Abstract readCase Reports
In one paragraph

Article in Journal of gynecologic oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Updates and evolving care paradigms for pre-menopausal patients with endometrial cancer.International journal of gynecological cancer : official journal of the International Gynecological Cancer Society · 2026
    Review
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xintong Yang *Shanghai Medical College of Fudan University, Shanghai, China.ORCID 0009-0007-5021-1040
Yu Xue *Department of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.ORCID 0000-0001-8319-6691
Wenyu ShaoDepartment of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.ORCID 0000-0001-8853-1735
Weiwei ShanDepartment of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.ORCID 0000-0001-6729-2683
Zhiying XuDepartment of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.ORCID 0000-0001-7114-6814
Yiqin WangDepartment of Pathology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.ORCID 0000-0002-8424-6053
Xiaojun ChenDepartment of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.ORCID 0000-0002-5493-1500

Funding

NKRDPC 2022YFC2704305Shanghai Technical Innovation Program 20Z11900700
6 · The paper itself

Abstract

objectiveTo evaluate the efficacy of immune checkpoint inhibitors (ICIs) for fertility-sparing treatment in Lynch syndrome-associated endometrial cancer (LS-EC).

methodsFour LS-EC cases received programmed cell death protein 1 (PD-1) inhibitors for fertility preservation at the Obstetrics and Gynecology Hospital of Fudan University from 2017 to 2023. The clinical data and long-term outcomes were retrospectively reviewed.

resultsCase 1, carrying germline

conclusionICIs might be an effective choice for LS-EC patients desiring fertility preservation.

Indexed as

Colorectal Neoplasms, Hereditary NonpolyposisEndometrial NeoplasmsFertility PreservationImmune Checkpoint InhibitorsAdultFemaleHumansMutL Protein Homolog 1MutS Homolog 2 ProteinRetrospective StudiesTreatment OutcomeImmune Checkpoint InhibitorsMLH1 protein, humanMSH2 protein, humanMutL Protein Homolog 1MutS Homolog 2 ProteinEndometrial CancerFertility-Preserving TreatmentImmune Checkpoint InhibitorsLynch Syndrome

Identifiers

PMID39853260
PMCPMC12226331

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.