Evidence map›Paper›PMID 39853058›Full record

ReviewToxics2025

Blood Trihalomethanes and Human Cancer: A Systematic Review and Meta-Analysis.

Miaomiao Fu, Pengyu Xue, Zhuorong Du, Jingsi Chen, Xiaojun Liang, Jiafu Li

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Toxics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Miaomiao FuSchool of Public Health, MOE Key Laboratory of Geriatric Diseases and Immunology Suzhou Medical College, Soochow University, Suzhou 215123, China.
Pengyu XueSchool of Public Health, MOE Key Laboratory of Geriatric Diseases and Immunology Suzhou Medical College, Soochow University, Suzhou 215123, China.
Zhuorong DuSchool of Public Health, MOE Key Laboratory of Geriatric Diseases and Immunology Suzhou Medical College, Soochow University, Suzhou 215123, China.ORCID 0009-0008-4231-8873
Jingsi ChenSchool of Public Health, MOE Key Laboratory of Geriatric Diseases and Immunology Suzhou Medical College, Soochow University, Suzhou 215123, China.
Xiaojun LiangKunshan Center for Disease Control and Prevention, Suzhou 215301, China.
Jiafu LiSchool of Public Health, MOE Key Laboratory of Geriatric Diseases and Immunology Suzhou Medical College, Soochow University, Suzhou 215123, China.ORCID 0000-0002-2576-2189

Funding

2024 Hygiene Talent Plan of Gusu not applicableHigh Level Talent Plan of Kunshan not applicableInnovative Leading Talents of Gusu ZXL2023208Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) not applicableSuzhou Found for Prevention and Control Technology of Critical Illness and Infectious Diseases GWZX202204
6 · The paper itself

Abstract

The control of waterborne diseases through water disinfection is a significant advancement in public health. However, the disinfection process generates disinfection by-products (DBPs), including trihalomethanes (THMs), which are considered to influence the occurrence of cancer. This analysis aims to quantitatively evaluate the relationship between blood concentrations of THMs and cancer. Additionally, the relationship between blood chloroform concentration and cancer is analyzed separately. Following PRISMA guidelines, we conducted a thorough search in the PubMed, Web of Science, and CNKI databases. Statistical analysis was performed using Review Manager 5.4 software. After screening, seven studies meeting the evaluation criteria were included. A total of 1027 blood samples from patients with cancer and 7351 blood samples from the control group were collected. The average concentration of THMs in the blood of the experimental group was 46.71 pg/mL, while it was 36.406 pg/mL in the control group. The difference between the two groups was statistically significant (SMD = -0.36, 95% CI: -0.45 to -0.27,

Indexed as

bloodcancerchloroformtrihalomethanes

Identifiers

PMID39853058
PMCPMC11768473

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.