Evidence map›Paper›PMID 39852980›Full record

Observational studyToxins2025

Does Clostridium Perfringens Epsilon Toxin Mimic an Auto-Antigen Involved in Multiple Sclerosis?

Marie-Lise Gougeon, Valérie Seffer, Cezarela Hoxha, Elisabeth Maillart, Michel R Popoff

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Toxins, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Marie-Lise GougeonUnité Immunité Innée et Virus, Institut Pasteur, 25-28 rue du Dr. Roux, 75724 Paris, Cedex 15, France.ORCID 0000-0001-7531-7713
Valérie SefferUnité Immunité Innée et Virus, Institut Pasteur, 25-28 rue du Dr. Roux, 75724 Paris, Cedex 15, France.
Cezarela HoxhaUnité des Toxines Bactériennes, Institut Pasteur, Université Paris Cité, CNRS UMR 2001 INSERM U1306, 75015 Paris, France.
Elisabeth MaillartDépartement de Neurologie, AP-HP, Hôpital Pitié-Salpêtrière, Multiple Sclerosis Center, 75015 Paris, France.ORCID 0000-0001-7699-0328
Michel R PopoffUnité des Toxines Bactériennes, Institut Pasteur, Université Paris Cité, CNRS UMR 2001 INSERM U1306, 75015 Paris, France.ORCID 0000-0001-9305-8989

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiple sclerosis (MS) is a chronic immune-mediated neurological disorder, characterized by progressive demyelination and neuronal cell loss in the central nervous system. Many possible causes of MS have been proposed, including genetic factors, environmental triggers, and infectious agents. Recently,

Indexed as

AutoantibodiesAutoantigensBacterial ToxinsMultiple Sclerosis, Relapsing-RemittingAdultAntibodies, BacterialCase-Control StudiesClostridium perfringensFemaleHumansImmunoglobulin AImmunoglobulin GImmunoglobulin MMaleMiddle AgedMolecular MimicryAntibodies, BacterialAutoantibodiesAutoantigensBacterial ToxinsClostridium perfringens epsilon-toxinImmunoglobulin AImmunoglobulin GImmunoglobulin MClostridium perfringensEDSSepsilon toxin ETXIgA antibodiesIgGIgMmultiple sclerosis

Identifiers

PMID39852980
PMCPMC11768822

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.