Evidence map›Paper›PMID 39852800›Full record

ArticleVaccines2024

Cell Wall Protein 2 as a Vaccine Candidate Protects Mice Against

Shaohui Wang, Joshua Heuler, Jessica Bullock, Junling Qin, Soumyadeep Chakraborty, Agbendeh Lubem Nathaniel, Shifeng Wang, Xingmin Sun

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shaohui WangDepartment of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33620, USA.ORCID 0000-0002-4735-1225
Joshua HeulerDepartment of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33620, USA.
Jessica BullockDepartment of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33620, USA.
Junling QinDepartment of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33620, USA.
Soumyadeep ChakrabortyDepartment of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33620, USA.ORCID 0000-0002-3882-7172
Agbendeh Lubem NathanielDepartment of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33620, USA.ORCID 0000-0003-4704-0571
Shifeng WangDepartment of Infectious Diseases and Immunology, College of Veterinary Medicine, University of Florida, Gainesville, FL 33620, USA.
Xingmin SunDepartment of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33620, USA.

Funding

Multivalent vaccines against Clostridium difficile infectionR01AI132711 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI Xingmin Sun, Shifeng Wang · 2017 to 2026
$3.3M
Novel polymer biomaterials combating C. difficile infectionR01AI149852 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI CAI, JIANFENG, SUN, XINGMIN · 2019 to 2023
$1.9M
Development of probiotic-based and Clostridioides difficile-targeted therapeuticsR21AI183094 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI SUN, XINGMIN, ZHANG, YONGRONG · 2024 to 2025
$431k
Effect of bile salt hydrolase inhibitors on Clostridium difficile infectionR21AI159745 · NIAID · UNIVERSITY OF TENNESSEE KNOXVILLE · PI LIN, JUN, SUN, XINGMIN · 2021 to 2022
$416k
Anthony Gagliard Foundation n/aFlorida High Tech Corridor Early-Stage Innovation Award n/aNIAID NIH HHS R01 AI132711NIAID NIH HHS R01 AI149852NIAID NIH HHS R21 AI159745NIAID NIH HHS R21 AI183094NIH HHS 2R01-AI132711, R21-AI83094, R01-AI149852, R21-AI159745USF Center for Antimicrobial Resistance n/a
6 · The paper itself

Abstract

BACKGROUND/

objectives

methodswe conducted in silico analyses to assess the homology and immunogenicity of Cwp2, and we evaluated its potential as a vaccine candidate against CDI using a mouse model of immunization and infection.

resultsOur in silico analyses predicted the immunogenic region (functional domain) of Cwp2 and revealed its high homology among various toxinotypes and ribotypes (R.T.s) or sequence types (S.T.s). Immunizations of mice with the Cwp2 functional domain (Cwp2_A) induced potent IgG/A antibody responses against Cwp2_A, protected mice from CDI, and reduced

conclusionsOur report demonstrates for the first time the potential of Cwp2_A as an effective vaccine candidate against CDI in mice.

Indexed as

Clostridioides difficile infection (CDI)colonizationCwp2vaccine

Identifiers

PMID39852800
PMCPMC11768939

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.