ArticleNeurology international2025
Endocrine Outcome and Quality of Life After Transsphenoidal Resection of Pituitary Adenoma-A Prospective Randomized Single-Blinded Study Comparing Endoscopic Versus Microscopic Resection.
Article in Neurology international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03515603 (Compare Between Endoscopic and Microsurgical Transsphenoidal Resection of Pituitary Adenomas With Intraoperative MRI), which is not on this map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Compare Between Endoscopic and Microsurgical Transsphenoidal Resection of Pituitary Adenomas With Intraoperative MRI
Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Outcomes of endoscopic and microscopic transsphenoidal pituitary surgery: evidence from a systematic review, meta-analysis, and institutional experience.Neurosurgical review · 2026Pooled it
- Article
- Analysis of the factors affecting the quality of life in patients with pituitary adenomas before and after endoscopic transsphenoidal surgery.Frontiers in endocrinology · 2026Article
- Article
- Article
- Effectiveness of transsphenoidal surgery on remission and recurrence rates of pituitary adenomas: A systematic review and meta-analysis.Tzu chi medical journalArticle
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Authors and funding
9 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundEndoscopic pituitary surgery might yield better endocrine outcomes compared to microscopic resection. We conducted a prospective, randomized, single-blinded study to compare the endocrine outcome and quality of life (QoL) of patients with newly diagnosed pituitary adenoma who underwent either endoscopic or microscopic transsphenoidal surgery (NCT03515603).
methodsDue to slow recruitment, this study had to be stopped prematurely. Out of 170 transsphenoidal pituitary surgeries performed during the study period, 36 patients were enrolled in this study. The primary endpoint was based on the development of a new hypopituitarism. Secondary endpoints included the extent of resection, complications, and QoL.
resultsEndoscopic surgery was performed in 47.2% (n = 17). A new hypopituitarism was found in 8.3% (n = 3). All these cases underwent microscopic resection. Arginine vasopressin deficiency was found in 2.7% (n = 1) after microscopic resection. Gross total resection was achieved in 94.4% (n = 34). No surgical complications or new neurological deficits were observed. QoL improved significantly after the surgery, as measured by EQ-VAS (
conclusionThe endoscopic technique appears to offer benefits in the treatment of pituitary adenomas, particularly in terms of achieving a favorable endocrine outcome.
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