Evidence map›Paper›PMID 39852694›Full record

ArticleNanomaterials (Basel, Switzerland)2025

Well-Characterized Polyethyleneimine-/Carboxylated-Polyethylene-Glycol-Functionalized Gold Nanoparticles as Prospective Nanoscale Control Materials for In Vitro Cell Viability Assays: Particle Characterization and Toxicity Tests in Eight Mammalian Cell Lines.

Vytas Reipa, Vincent A Hackley, Alessandro Tona, Min Beom Heo, Ye Ryeong Lee, Tae Geol Lee, Aaron Johnston-Peck, Tae Joon Cho

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Vytas ReipaMaterials Measurement Laboratory, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA.ORCID 0000-0001-6984-4146
Vincent A HackleyMaterials Measurement Laboratory, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA.
Alessandro TonaMaterials Measurement Laboratory, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA.
Min Beom HeoDivision of Biomedical Metrology, Korea Research Institute of Standards and Science, Daejeon 34113, Republic of Korea.
Ye Ryeong LeeDivision of Biomedical Metrology, Korea Research Institute of Standards and Science, Daejeon 34113, Republic of Korea.
Tae Geol LeeDivision of Biomedical Metrology, Korea Research Institute of Standards and Science, Daejeon 34113, Republic of Korea.ORCID 0000-0002-6674-4147
Aaron Johnston-PeckMaterials Measurement Laboratory, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA.
Tae Joon ChoMaterials Measurement Laboratory, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA.ORCID 0000-0001-9467-0491

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The safety screening of manufactured nanomaterials (MNMs) is essential for their adoption by consumers and the marketplace. Lately, animal-based testing has been replaced by mechanistically informative in vitro assays due to the requirements of regulatory agencies. Cell viability assays are widely employed for manufactured nanomaterial hazard screening as a first-tier approach. Critical parts of such assays are positive and negative controls that serve as measurement benchmarks. We present the cellular viability and corresponding particle characterization obtained with eight different cell lines that were exposed to Au-PEI and Au-PEG-COOH nanoparticles. We showed that polyethyleneimine- and carboxylate-polyethylene-glycol-conjugated gold nanoparticles (AuPEI and Au-PEG-COOH) qualified for positive and negative controls in the in vitro cell viability assays used for MNM toxicological screening.

Indexed as

assay controlscell viabilitygold nanoparticlesMTSpolyethylene glycolpolyethylene imine

Identifiers

PMID39852694
PMCPMC11767793

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.