Evidence map›Paper›PMID 39852524›Full record

ArticleMarine drugs2025

Selenium-Chondroitin Sulfate Nanoparticles Inhibit Angiogenesis by Regulating the VEGFR2-Mediated PI3K/Akt Pathway.

Xia Zheng, Xiaofei Liu, Zhuo Wang, Rui Li, Qiaoli Zhao, Bingbing Song, Kit-Leong Cheong, Jianping Chen, Saiyi Zhong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Marine drugs, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xia ZhengCollege of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, China.
Xiaofei LiuCollege of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, China.
Zhuo WangCollege of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, China.
Rui LiCollege of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, China.ORCID 0000-0001-5953-2341
Qiaoli ZhaoCollege of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, China.
Bingbing SongCollege of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, China.
Kit-Leong CheongCollege of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, China.ORCID 0000-0001-8380-0123
Jianping ChenCollege of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, China.
Saiyi ZhongCollege of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, China.

Funding

Science and Technology of Zhanjiang City No. 2022A01045
6 · The paper itself

Abstract

Chondroitin sulfate (CS), a class of glycosaminoglycans covalently attached to proteins to form proteoglycans, is widely distributed in the extracellular matrix and cell surface of animal tissues. In our previous study, CS was used as a template for the synthesis of seleno-chondroitin sulfate (SeCS) through the redox reaction of ascorbic acid (Vc) and sodium selenite (Na

Indexed as

Angiogenesis InhibitorsChondroitin SulfatesNanoparticlesSeleniumVascular Endothelial Growth Factor Receptor-2AngiogenesisAnimalsCell MovementChick EmbryoChorioallantoic MembraneHumansHuman Umbilical Vein Endothelial CellsPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktSignal TransductionAngiogenesis InhibitorsChondroitin SulfatesKDR protein, humanPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktSeleniumVascular Endothelial Growth Factor Receptor-2angiogenesischick embryo chorionic allantoic assayhuman umbilical vein endothelial cellsselenium–chondroitin sulfateVEGFR2 protein

Identifiers

PMID39852524
PMCPMC11766607

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.