Evidence map›Paper›PMID 39852477›Full record

ArticleJournal of fungi (Basel, Switzerland)2025

Direct and Indirect Protein Interactions Link FUS Aggregation to Histone Post-Translational Modification Dysregulation and Growth Suppression in an ALS/FTD Yeast Model.

Seth A Bennett, Samantha N Cobos, Raven M A Fisher, Elizaveta Son, Rania Frederic, Rianna Segal, Huda Yousuf, Kaitlyn Chan, David K Dansu, Mariana P Torrente

Abstract read
In one paragraph

Article in Journal of fungi (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Seth A BennettDepartment of Chemistry and Biochemistry, Brooklyn College, Brooklyn, NY 11210, USA.
Samantha N CobosDepartment of Chemistry and Biochemistry, Brooklyn College, Brooklyn, NY 11210, USA.
Raven M A FisherDepartment of Chemistry and Biochemistry, Brooklyn College, Brooklyn, NY 11210, USA.
Elizaveta SonDepartment of Chemistry and Biochemistry, Brooklyn College, Brooklyn, NY 11210, USA.
Rania FredericDepartment of Chemistry and Biochemistry, Brooklyn College, Brooklyn, NY 11210, USA.
Rianna SegalDepartment of Chemistry and Biochemistry, Brooklyn College, Brooklyn, NY 11210, USA.
Huda YousufDepartment of Chemistry and Biochemistry, Brooklyn College, Brooklyn, NY 11210, USA.
Kaitlyn ChanDepartment of Chemistry and Biochemistry, Brooklyn College, Brooklyn, NY 11210, USA.
David K DansuPh.D. Program in Biochemistry, The Graduate Center of the City University of New York, New York, NY 10016, USA.ORCID 0000-0003-0342-3060
Mariana P TorrenteDepartment of Chemistry and Biochemistry, Brooklyn College, Brooklyn, NY 11210, USA.ORCID 0000-0001-8220-2228

Funding

IRACDA - The New York Consortium for the Advancement of Postdoctoral Scholars (NY CAPS)Phase IIK12GM102778 · NIGMS · STATE UNIVERSITY NEW YORK STONY BROOK · PI Carol A. Carter, Karian Janice Wright · 2012 to 2026
$13.1M
Environmental Biosensors in the Oligodendrocyte LineageR35NS111604 · NINDS · ADVANCED SCIENCE RESEARCH CENTER · PI Patrizia Casaccia · 2019 to 2026
$9.1M
Acquisition of an Orbitrap Elite Mass Spectrometer with ETDS10OD010582 · OD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI UEBERHEIDE, BEATRIX MAGDALENA · 2013 to 2013
$600k
New Targets in C9orf72 FTD: Exploring Histone H3 S10 PhosphorylationR15NS125394 · NINDS · BROOKLYN COLLEGE · PI TORRENTE, MARIANA PLAZAS · 2022 to 2023
$575k
Epigenetics In Neurodegenerative Disease: Targeting Histone Modifications in ALSK22NS091314 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI TORRENTE, MARIANA PLAZAS · 2015 to 2017
$536k
Brooklyn College, CUNY N/ANIGMS NIH HHS K12 GM102778NIH HHS 1S01OD010582-01A1NIH HHS S10 OD010582NIH NIGMS K12GM102778NIH NINDS K22NS09131401NIH NINDS R15NS125394NIH NINDS R15NS125394-01S1NIH NINDS R35NS111604NINDS NIH HHS K22 NS091314NINDS NIH HHS R15 NS125394NINDS NIH HHS R35 NS111604The Graduate Center, CUNY N/A
6 · The paper itself

Abstract

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are incurable neurodegenerative disorders sharing pathological and genetic features, including mutations in the

Indexed as

amyotrophic lateral sclerosisepigeneticsfrontotemporal dementiaFUShistone post-translational modificationsIpl1Nop1Rtt109

Identifiers

PMID39852477
PMCPMC11766905

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.