Evidence map›Paper›PMID 39852374›Full record

ArticleMetabolites2025

Effects of Nicotinamide Riboside Supplementation on Postmortem Mitochondrial Functionality and Apoptotic Activation.

Chen Zhu, Luke A Whitcomb, Adam J Chicco, Morgan E Gravely, Hanna M Alcocer, Daniela A Alambarrio, John M Gonzalez, Colton L Smith, Mahesh N Nair, Huey Yi Loh and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Metabolites, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Chen ZhuDepartment of Animal Science, University of Connecticut, Storrs, CT 06269, USA.
Luke A WhitcombDepartment of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA.
Adam J ChiccoDepartment of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA.
Morgan E GravelyDepartment of Animal and Dairy Science, University of Georgia, Athens, GA 30602, USA.
Hanna M AlcocerDepartment of Animal and Dairy Science, University of Georgia, Athens, GA 30602, USA.
Daniela A AlambarrioDepartment of Animal and Dairy Science, University of Georgia, Athens, GA 30602, USA.
John M GonzalezDepartment of Animal and Dairy Science, University of Georgia, Athens, GA 30602, USA.ORCID 0000-0002-1905-9294
Colton L SmithDepartment of Animal Sciences, Colorado State University, Fort Collins, CO 80523, USA.
Mahesh N NairDepartment of Animal Sciences, Colorado State University, Fort Collins, CO 80523, USA.ORCID 0000-0002-2917-1028
Huey Yi LohDepartment of Animal Sciences, Colorado State University, Fort Collins, CO 80523, USA.ORCID 0009-0009-5603-8343
Terry E EngleDepartment of Animal Sciences, Colorado State University, Fort Collins, CO 80523, USA.
Arya NiraulaDepartment of Animal Science, University of Connecticut, Storrs, CT 06269, USA.
Chaoyu ZhaiDepartment of Animal Science, University of Connecticut, Storrs, CT 06269, USA.ORCID 0000-0001-5148-4584

Funding

USDA National Institute of Food and Agriculture 2020-67015-31560
6 · The paper itself

Abstract

BACKGROUND/

objectivesEarly postmortem mitochondrial function and apoptotic activation affect meat quality development. Nicotinamide riboside (NR) supplementation to pigs prior to harvest can improve pork color stability, but its mechanism remains unclear. This study aimed to evaluate the impact of NR supplementation on early postmortem mitochondrial functionality and apoptosis.

methodsSixteen pigs (

resultsNR-supplemented muscle exhibited lower proton leak-associated respiration at 45 min postmortem (

conclusionsNR supplementation demonstrated the potential to protect mitochondrial integral function and alleviate apoptotic activation in early postmortem porcine skeletal muscle, which might contribute to a higher meat color stability in NR-supplemented pork during retail display.

Indexed as

apoptosismitochondrial functionnicotinamide ribosideporcine longissimuspostmortem muscle

Identifiers

PMID39852374
PMCPMC11766954

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.