Resonant Young's Slit Interferometer for Sensitive Detection of Low-Molecular-Weight Biomarkers.

Stefanus Renaldi Wijaya, Augusto Martins, Katie Morris, Steven D Quinn, Thomas F Krauss

Abstract read

In one paragraph

Article in Biosensors, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Ultrasensitive Alzheimer's disease biomarker detection with nanopillar photonic crystal biosensors.Optica · 2025
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Stefanus Renaldi WijayaSchool of Physics, Engineering and Technology, University of York, York YO10 5DD, UK.ORCID 0009-0000-9742-5870

Augusto MartinsSchool of Physics, Engineering and Technology, University of York, York YO10 5DD, UK.

Katie MorrisSchool of Physics, Engineering and Technology, University of York, York YO10 5DD, UK.ORCID 0000-0002-8944-2264

Steven D QuinnSchool of Physics, Engineering and Technology, University of York, York YO10 5DD, UK.ORCID 0000-0003-3442-4103

Thomas F KraussSchool of Physics, Engineering and Technology, University of York, York YO10 5DD, UK.

Funding

Alzheimer's Research UK RF2019-A-001Alzheimer's Society AS-PG-22-043Engineering and Physical Sciences Research Council EP/V047434/1Engineering and Physical Sciences Research Council EP/X037770/1

6 · The paper itself

Abstract

The detection of low-molecular-weight biomarkers is essential for diagnosing and managing various diseases, including neurodegenerative conditions such as Alzheimer's disease. A biomarker's low molecular weight is a challenge for label-free optical modalities, as the phase change they detect is directly proportional to the mass bound on the sensor's surface. To address this challenge, we used a resonant Young's slit interferometer geometry and implemented several innovations, such as phase noise matching and optimisation of the fringe spacing, to maximise the signal-to-noise ratio. As a result, we achieved a limit of detection of 2.9 × 10

Indexed as

Amyloid beta-PeptidesBiomarkersBiosensing TechniquesInterferometryAlzheimer DiseaseHumansMolecular WeightAmyloid beta-PeptidesBiomarkersbiosensorsguided-mode resonancelimit of detectionoptical sensorsYoung’s interferometer

Identifiers

PMID39852100

DOI10.3390/bios15010050

PMCPMC11763694

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.