Evidence map›Paper›PMID 39852031›Full record

ArticleGels (Basel, Switzerland)2025

Injectable Chitosan Hydrogel Particles as Nasal Packing Materials After Endoscopic Sinus Surgery for Treatment of Chronic Sinusitis.

Yusuke Yamashita, Kei Hosoya, Yukio Fujiwara, Yoichi Saito, Masahiro Yoshida, Shoji Matsune, Kimihiro Okubo, Takayuki Takei

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gels (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yusuke YamashitaDepartment of Chemical Engineering, Graduate School of Science and Engineering, Kagoshima University, 1-21-40 Korimoto, Kagoshima 890-0065, Japan.
Kei HosoyaNose and Smell Clinic Ikebukuro, Tokyo 171-0022, Japan.
Yukio FujiwaraDepartment of Cell Pathology, Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan.ORCID 0000-0002-2074-0597
Yoichi SaitoLaboratory of Bioengineering, Faculty of Advanced Science and Technology, Kumamoto University, 2-39-1 Kurokami, Chuo-ku, Kumamoto 860-8555, Japan.ORCID 0000-0001-9097-7656
Masahiro YoshidaDepartment of Chemical Engineering, Graduate School of Science and Engineering, Kagoshima University, 1-21-40 Korimoto, Kagoshima 890-0065, Japan.
Shoji MatsuneDepartment of Otolaryngology, Musashi Kosugi Hospital, Nippon Medical School, Kanagawa 211-8533, Japan.
Kimihiro OkuboDepartment of Otorhinolaryngology, Nippon Medical School, Tokyo 113-8602, Japan.ORCID 0000-0002-9900-4284
Takayuki TakeiDepartment of Chemical Engineering, Graduate School of Science and Engineering, Kagoshima University, 1-21-40 Korimoto, Kagoshima 890-0065, Japan.ORCID 0000-0001-7985-1649

Funding

Japan Agency for Medical Research and Development JP22ym0126814
6 · The paper itself

Abstract

After endoscopic sinus surgery (ESS), nasal packing is often used to stop bleeding and promote wound healing. Because maintaining a moist environment is important to enhance wound healing, hydrogel-based wound dressings are effective to promote wound healing. Chitosan is used in the medical field because of its high hemostatic and wound healing properties. We developed a pH-neutral and non-toxic chitosan hydrogel, which was difficult to achieve using conventional methods. In this study, we show in animal experiments that the chitosan hydrogel (hydrogel particles) had higher wound healing properties than a commercially available solid wound dressing (dry state) composed of the same polymer. Additionally, we applied the injectable chitosan hydrogel particles as nasal packing materials to patients with bilateral chronic sinusitis undergoing ESS in a pilot clinical study. Concerning symptom scores, though the results narrowly missed statistical differences (

Indexed as

chitosanchronic sinusitisendoscopic sinus surgeryhemostasishydrogelnasal packingwound healing

Identifiers

PMID39852031
PMCPMC11764751

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.