Evidence map›Paper›PMID 39851572›Full record

ReviewCells2025

The Link Between Venous and Arterial Thrombosis: Is There a Role for Endothelial Dysfunction?

Marco Paolo Donadini, Francesca Calcaterra, Erica Romualdi, Roberta Ciceri, Assunta Cancellara, Corrado Lodigiani, Monica Bacci, Silvia Della Bella, Walter Ageno, Domenico Mavilio

Abstract readReview
In one paragraph

Review in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Potential Role of Polyphenols in Platelet Aggregation and Blood Coagulation.Journal of cardiovascular development and disease · 2026
    Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Pulmonary infection byFrontiers in cellular and infection microbiology · 2026
    Article
  12. Review
  13. Managing patients with a history of arterial disease and new venous thromboembolism.Hematology. American Society of Hematology. Education Program · 2025
    Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Targeted drug delivery systems for atherosclerosis.Journal of nanobiotechnology · 2025
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Marco Paolo DonadiniDepartment of Medicine and Surgery, Research Center on Thromboembolic Diseases and Antithrombotic Therapies, University of Insubria, 21100 Varese, Italy.ORCID 0000-0001-5065-318X
Francesca CalcaterraDepartment of Medical Biotechnologies and Translational Medicine, University of Milan, 20125 Milan, Italy.
Erica RomualdiCentro Trombosi e TAO, Azienda Socio Sanitaria Territoriale dei Sette Laghi, 21100 Varese, Italy.ORCID 0000-0002-6356-3631
Roberta CiceriDepartment of Medical Biotechnologies and Translational Medicine, University of Milan, 20125 Milan, Italy.ORCID 0000-0003-2323-0346
Assunta CancellaraDepartment of Medical Biotechnologies and Translational Medicine, University of Milan, 20125 Milan, Italy.
Corrado LodigianiCenter for Thrombosis and Hemorrhagic Diseases, IRCCS Humanitas Research Hospital, 20089 Rozzano, Italy.ORCID 0000-0002-9152-9385
Monica BacciCenter for Thrombosis and Hemorrhagic Diseases, IRCCS Humanitas Research Hospital, 20089 Rozzano, Italy.ORCID 0000-0002-5702-9408
Silvia Della BellaDepartment of Medical Biotechnologies and Translational Medicine, University of Milan, 20125 Milan, Italy.ORCID 0000-0003-0818-5049
Walter AgenoDepartment of Medicine and Surgery, Research Center on Thromboembolic Diseases and Antithrombotic Therapies, University of Insubria, 21100 Varese, Italy.ORCID 0000-0002-1922-8879
Domenico MavilioDepartment of Medical Biotechnologies and Translational Medicine, University of Milan, 20125 Milan, Italy.

Funding

Fondazione Cariplo 2020-3606Ministry of Health, Italy GR-2018-12365520
6 · The paper itself

Abstract

Venous thromboembolism (VTE) and arterial thrombosis (AT) are distinct yet closely related pathological processes. While traditionally considered separate entities, accumulating evidence suggests that they share common risk factors, such as inflammation and endothelial dysfunction (ED). This review explores the parallels and differences between venous and arterial thrombosis, with particular attention to the role of unprovoked VTE and its potential links to atherosclerosis and systemic inflammation. A key focus is the role of ED, which is emerging as a critical factor in thrombogenesis across both the venous and arterial systems. We examine the current methods for clinically detecting ED, including the use of biomarkers and advanced imaging techniques. Additionally, we discuss novel research avenues, such as the potential of endothelial colony-forming cells and other innovative methodologies, to further unravel the complex mechanisms of thrombosis. Finally, we propose future clinical scenarios where targeting endothelial health could pave the way for more effective prevention and treatment strategies in thrombosis management.

Indexed as

ArteriesEndothelium, VascularThrombosisVenous ThromboembolismAnimalsBiomarkersEndothelial CellsHumansInflammationRisk FactorsBiomarkersarterial thrombosis (AT)endothelial dysfunction (ED)venous thromboembolism (VTE)

Identifiers

PMID39851572
PMCPMC11763525

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.