ArticleCells2025
Derivation and Characterization of Isogenic
Katherine A Pohl, Xiangmei Zhang, Johnny Jeonghyun Ji, Linsey Stiles, Alfredo A Sadun, Xian-Jie Yang
Abstract read
In one paragraphArticle in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
6 authors.
Katherine A PohlJules Stein Eye Institute, Department of Ophthalmology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Xiangmei ZhangJules Stein Eye Institute, Department of Ophthalmology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Johnny Jeonghyun JiJules Stein Eye Institute, Department of Ophthalmology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Linsey StilesDepartment of Molecular and Medical Pharmacology, Davide Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Alfredo A SadunDoheny Eye Center, Department of Ophthalmology, University of California, Los Angeles, CA 91103, USA.
Xian-Jie YangJules Stein Eye Institute, Department of Ophthalmology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.ORCID 0000-0003-2866-7440 Funding
Vision Research Core at UCLAP30EY000331 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DAVID S WILLIAMS · 1985 to 2026
$16.8MVision Science Training ProgramT32EY007026 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Alapakkam P Sampath · 1985 to 2026
$5.7MNeuroprotection Mechanism for PhotoreceptorsR01EY026319 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI YANG, XIAN-JIE · 2016 to 2025
$4.1MUnderstanding OPA1 mutation-driven dominant optic atrophy using human PSC-derived retinal ganglion cellsF31EY033242 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI POHL, KATHERINE ANNE · 2021 to 2022
$88kNEI NIH HHS F31 EY033242NEI NIH HHS P30 EY000331NEI NIH HHS R01 EY026319NEI NIH HHS T32 EY007026NIH HHS 2R01EY026319, F31EY033242, P30EY000331
6 · The paper itselfAbstract
Dominant optic atrophy (DOA) is the most commonly inherited optic neuropathy. The majority of DOA is caused by mutations in the
Indexed as
GTP PhosphohydrolasesMutationOptic Atrophy, Autosomal DominantPluripotent Stem CellsCell LineCRISPR-Cas SystemsGene EditingHumansInduced Pluripotent Stem CellsMitochondriaRetinal Ganglion CellsGTP PhosphohydrolasesOPA1 protein, humanCRISPR-Cas9 editingdominant optic atrophyisogenic human pluripotent stem cell linesmitochondriaOPA1 gene
Identifiers
PMID39851566
PMCPMC11764107
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