Evidence map›Paper›PMID 39851557›Full record

ArticleCells2025

Association of Structural Maintenance of Chromosome-1A Phosphorylation with Progression of Breast Cancer.

Sushma Yadav, Claudia M Kowolik, Daniel Schmolze, Yuan Yuan, Min Lin, Arthur D Riggs, David A Horne

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sushma YadavDepartment of Cancer Biology and Molecular Medicine, City of Hope National Medical Center, Duarte, CA 91010, USA.ORCID 0000-0003-1716-9446
Claudia M KowolikDepartment of Cancer Biology and Molecular Medicine, City of Hope National Medical Center, Duarte, CA 91010, USA.
Daniel SchmolzeDepartment of Pathology, City of Hope National Medical Center, Duarte, CA 91010, USA.
Yuan YuanBreast Oncology, Cedars-Sinai Cancer Medical Center, Los Angeles, CA 90048, USA.
Min LinDepartment of Cancer Biology and Molecular Medicine, City of Hope National Medical Center, Duarte, CA 91010, USA.
Arthur D RiggsDiabetes and Metabolism Research Institute, City of Hope National Medical Center, Duarte, CA 91010, USA.
David A HorneDepartment of Cancer Biology and Molecular Medicine, City of Hope National Medical Center, Duarte, CA 91010, USA.

Funding

Transgenic Mouse FacilityP30CA033572 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI John Charles Williams · 1985 to 2026
$86.3M
NCI NIH HHS P30 CA033572NIH HHS P30CA33572
6 · The paper itself

Abstract

Structural maintenance of chromosome-1A (SMC1A) is overexpressed in various malignancies including triple-negative breast cancer (TNBC). As a core component of the cohesin complex, SMC1A was initially recognized for its involvement in chromosomal cohesion and DNA-repair pathways. However, recent studies have unveiled its pivotal role in epithelial-mesenchymal transition (EMT), metastasis, and chemo- and radio-resistance in cancer cells. In hepatocellular carcinoma, aberrant phosphorylation of SMC1A has been associated with enhanced cell proliferation and migration. Despite these insights, the precise role of SMC1A phosphorylation in breast cancer remains largely unexplored. This study represents the first investigation to test the phosphorylation status and subcellular localization of SMC1A (p-SMC1A) in breast cancer and normal breast tissues. Immunohistochemical (IHC) staining was conducted using previously validated phospho-SMC1A antibodies on a histological section and tissue microarray (TMA) comprising samples from primary, invasive, and metastatic breast cancer and normal breast tissues. Our results revealed that p-SMC1A staining intensity was lower in normal breast tissues compared to invasive or metastatic breast cancer tissues (

Indexed as

Breast NeoplasmsCell Cycle ProteinsChromosomal Proteins, Non-HistoneDisease ProgressionStructural Maintenance of Chromosome Protein 1Cell Line, TumorEpithelial-Mesenchymal TransitionFemaleHumansMiddle AgedPhosphorylationCell Cycle ProteinsChromosomal Proteins, Non-HistoneStructural Maintenance of Chromosome Protein 1breast cancerimmunohistochemistrymetastasisphosphorylationstructural maintenance of chromosome-1Atumor progression

Identifiers

PMID39851557
PMCPMC11764376

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.