Evidence map›Paper›PMID 39851523›Full record

ArticleCells2025

Gene-Environment Interaction: Small Deletions (DELs) and Transcriptomic Profiles in Non-Melanoma Skin Cancer (NMSC) and Potential Implications for Therapy.

Farzana Jasmine, Armando Almazan, Yuliia Khamkevych, Maria Argos, Mohammad Shahriar, Tariqul Islam, Christopher R Shea, Habibul Ahsan, Muhammad G Kibriya

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Farzana JasmineInstitute for Population and Precision Health (IPPH), University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0002-5980-1174
Armando AlmazanInstitute for Population and Precision Health (IPPH), University of Chicago, Chicago, IL 60637, USA.
Yuliia KhamkevychInstitute for Population and Precision Health (IPPH), University of Chicago, Chicago, IL 60637, USA.
Maria ArgosDepartment of Environmental Health, School of Public Health, Boston University, Boston, MA 02118, USA.ORCID 0000-0003-4234-252X
Mohammad ShahriarInstitute for Population and Precision Health (IPPH), University of Chicago, Chicago, IL 60637, USA.
Tariqul IslamUChicago Research Bangladesh (URB), University of Chicago, Dhaka 1230, Bangladesh.
Christopher R SheaDivision of Dermatology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA.
Habibul AhsanInstitute for Population and Precision Health (IPPH), University of Chicago, Chicago, IL 60637, USA.
Muhammad G KibriyaInstitute for Population and Precision Health (IPPH), University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0001-9784-6958

Funding

Chemoprevention of arsenic-induced skin cancerR01CA107431 · NCI · UNIVERSITY OF CHICAGO · PI AHSAN, HABIBUL · 2005 to 2014
$17.3M
Pilot Program CoreP30ES027792 · NIEHS · UNIVERSITY OF CHICAGO · PI Gokhan M. Mutlu, Gail S Prins · 2017 to 2026
$13.6M
NCI NIH HHS R01 CA107431NIEHS NIH HHS P30 ES027792NIH HHS P30ES027792NIH HHS R01CA107431
6 · The paper itself

Abstract

Arsenic (As) is a risk factor for non-melanoma skin cancer (NMSC). From a six-year follow-up study on 7000 adults exposed to As, we reported the associations of single-nucleotide variation in tumor tissue and gene expression. Here, we identify the associations of small deletions (DELs) and transcriptomic profiles in NMSC. Comparing the (a) NMSC tissue (

Indexed as

Gene-Environment InteractionSequence DeletionSkin NeoplasmsTranscriptomeAdultAgedArsenicFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticHumansMaleMiddle AgedArsenicarsenicbasal-cell carcinomagene–environment interactionIL-17 signalingimmune checkpoint inhibitorsnon-melanoma skin cancershort tandem repeatsmall deletionsomatic mutationTGF-β signaling

Identifiers

PMID39851523
PMCPMC11764317

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.