Evidence map›Paper›PMID 39851493›Full record

ArticleCells2025

810-nm Photobiomodulation Evokes Glutamate Release in Normal and Rotenone-Dysfunctional Cortical Nerve Terminals by Modulating Mitochondrial Energy Metabolism.

Silvia Ravera, Elisa Farsetti, Guido Maura, Manuela Marcoli, Matteo Bozzo, Chiara Cervetto, Andrea Amaroli

Abstract read
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. Transcranial near-infrared therapy restores synaptic resilience by reshaping signaling landscapes in sleep-deprived tauopathy.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
    Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Silvia RaveraDepartment of Experimental Medicine, University of Genova, 16132 Genova, Italy.ORCID 0000-0002-0803-1042
Elisa FarsettiDepartment of Pharmacy, Section of Pharmacology and Toxicology, University of Genova, 16148 Genova, Italy.ORCID 0009-0004-5429-5745
Guido MauraDepartment of Earth, Environment and Life Sciences (DISTAV), University of Genova, 16132 Genova, Italy.
Manuela MarcoliDepartment of Earth, Environment and Life Sciences (DISTAV), University of Genova, 16132 Genova, Italy.
Matteo BozzoDepartment of Earth, Environment and Life Sciences (DISTAV), University of Genova, 16132 Genova, Italy.ORCID 0000-0002-7452-3758
Chiara CervettoIRCCS Ospedale Policlinico San Martino, 16132 Genova, Italy.ORCID 0000-0001-8290-3008
Andrea AmaroliInteruniversity Center for the Promotion of the 3Rs Principles in Teaching and Research (Centro 3R), 56122 Pisa, Italy.ORCID 0000-0002-0494-7942

Funding

Fondo per la Ricerca di Ateneo (FRA) University of Genoa 100022-2024-FRA-2024-Amaroli
6 · The paper itself

Abstract

The dysfunction of mitochondria, the primary source of cellular energy and producer of reactive oxygen species (ROS), is associated with brain aging and neurodegenerative diseases. Scientific evidence indicates that light in the visible and near-infrared spectrum can modulate mitochondrial activity, a phenomenon known in medicine as photobiomodulation therapy (PBM-t). The beneficial effects of PBM-t on dementia and neurodegeneration have been reviewed in the literature. However, the molecular mechanisms underlying these findings have yet to be fully elucidated. This study investigates the mechanism behind dose-dependent glutamate release in nerve terminals after irradiation with 810 nm, 1 W for 60 s continuous, 1 cm

Indexed as

Cerebral CortexEnergy MetabolismGlutamic AcidLow-Level Light TherapyMitochondriaNerve EndingsRotenoneAnimalsOxidative PhosphorylationRatsReactive Oxygen SpeciesSynaptosomesGlutamic AcidReactive Oxygen SpeciesRotenoneglutamatelow-level laser therapylow-level light therapymitochondrial dysfunctionmitochondrial metabolismneuron degenerationsneurotoxic disorderoxidative phosphorylationphototherapysynaptosomes

Identifiers

PMID39851493
PMCPMC11764165

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.