Evidence map›Paper›PMID 39851457›Full record

ArticleBrain sciences2025

Differential Impact of Risk Factors for Cognitive Decline in Heterosexual and Sexual Minority Older Adults in England.

Riccardo Manca, Jason D Flatt, Annalena Venneri

Abstract read
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In one paragraph

Article in Brain sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Riccardo MancaDepartment of Life Sciences, Brunel University of London, Uxbridge UB8 3PH, UK.ORCID 0000-0003-1715-6442
Jason D FlattSchool of Public Health, University of Nevada Las Vegas, Las Vegas, NV 89119, USA.ORCID 0000-0003-1244-738X
Annalena VenneriDepartment of Life Sciences, Brunel University of London, Uxbridge UB8 3PH, UK.ORCID 0000-0002-9488-2301

Funding

Project-001R01AG017644 · NIA · UNIVERSITY OF LONDON INST OF NEUROLOGY · PI Andrew Steptoe · 2000 to 2026
$56.2M
Building Community and Research Engagement among Sexual and Gender Minority Older Adults at Risk for Alzheimer’s Disease and Related DementiasR24AG066599 · NIA · EMORY UNIVERSITY · PI ANDERSON, JOEL G., FLATT, JASON DANE · 2021 to 2023
$2.3M
Enhancing Measurement and Characterization of Roles and Experiences of Sexual and Gender Minority Caregivers of Persons living with Alzheimer's Disease and Related DementiasR01AG083177 · NIA · UNIVERSITY OF NEVADA LAS VEGAS · PI ANDERSON, JOEL G., DOWLING, NORCA MARITZA · 2023 to 2024
$1.4M
The Epidemiology of Alzheimer's Disease and Related Dementias in Sexual and Gender Minority Older Adults: Identifying Risk and Protective FactorsK01AG056669 · NIA · UNIVERSITY OF NEVADA LAS VEGAS · PI FLATT, JASON DANE · 2018 to 2022
$666k
Alzheimer's Association AARF-22-919481NIA NIH HHS K01 AG056669NIA NIH HHS R01 AG017644NIA NIH HHS R01 AG083177NIA NIH HHS R24 AG066599
6 · The paper itself

Abstract

BACKGROUND/

objectivesSexual minority older adults (SMOAs) report greater subjective cognitive decline (SCD) than heterosexual older adults (HOAs). This study aimed to compare the impact of multiple psycho-social risk factors on objective and subjective cognitive decline in HOAs and SMOAs.

methodsTwo samples of self-identified HOAs and SMOAs were selected from the English Longitudinal Study of Ageing. Reliable change indices for episodic and semantic memory were created to assess cognitive decline. SCD was self-reported for memory and general cognition. Depressive symptoms, loneliness, marital status and socio-economic status were investigated as risk factors.

resultsNo between-group differences were found in cognitive decline. Higher depression was associated with greater SCD risk and worse semantic memory decline. The latter effect was stronger in SMOAs. The findings were largely replicated in the sensitivity analysis.

conclusionsPoor mental health may represent the strongest driver of cognitive decline in SMOAs and to a greater extent than in HOAs.

Indexed as

cognitive declinelonelinessmarital statusmemorymental healthminoritysexual orientationsocio-economic status

Identifiers

PMID39851457
PMCPMC11764127

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.