Evidence map›Paper›PMID 39851451›Full record

ArticleBrain sciences2025

Enhanced Interleukin 6 Trans-Signaling Modulates Disease Process in Amyotrophic Lateral Sclerosis Mouse Models.

Carol Milligan, Dale O Cowley, William Stewart, Alyson M Curry, Elizabeth Forbes, Brian Rector, Annette Hastie, Liang Liu, Gregory A Hawkins

Abstract read
In one paragraph

Article in Brain sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Carol MilliganDepartment of Translational Neuroscience, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.
Dale O CowleyDepartment of Genetics and Animal Models Core Facility, University of North Carolina, Chapel Hill, NC 27599, USA.ORCID 0000-0001-5697-5817
William StewartDepartment of Translational Neuroscience, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.
Alyson M CurryDepartment of Translational Neuroscience, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.
Elizabeth ForbesDepartment of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.ORCID 0000-0003-3300-5476
Brian RectorDepartment of Internal Medicine Section on Pulmonary, Critical Care, Allergy and Immunologic Diseases, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.
Annette HastieDepartment of Internal Medicine Section on Pulmonary, Critical Care, Allergy and Immunologic Diseases, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.ORCID 0000-0001-6607-7797
Liang LiuDepartment of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.ORCID 0000-0001-8630-7430
Gregory A HawkinsDepartment of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.

Funding

Development of IL6 Transsignaling Mouse as Shared ResourceR03AI137866 · NIAID · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI HAWKINS, GREGORY A, MILLIGAN, CAROL · 2018 to 2019
$155k
NIAID NIH HHS R03 AI137866NIH HHS 1R03AI137866-21A1US Department of the Army DoD W81XWH1810377Wake Forest University School of Medicine Hope for Tomorrow ALS FundWake Forest University School of Medicine Neuroscience Clinical Trial and Innovation CenterWake Forest University School of Medicine TAB Williams Endowment
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

astrocytesglial cellsmicrogliamotoneuronsmotor neuron diseaseneuroimmuneneuromuscular junctions

Identifiers

PMID39851451
PMCPMC11764401

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.