ArticleBrain sciences2025
Peri-Traumatic Near-Infrared Light Treatment Attenuates the Severity of Noise-Induced Hearing Loss by Rescuing (Type I) Spiral Ganglion Neurons in Mice.
Article in Brain sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundPrevious studies have shown that multiple post-traumatic irradiations of the cochlea with near-infrared light (NIR) can significantly reduce noise-induced hearing loss. However, a single NIR pre-treatment was shown to have the same effect. Extending the pre-treatment time did not result in any further reduction in hearing loss. The present study investigated whether a combined NIR pre- and post-treatment had an increased effect on hearing preservation.
methodsFrequency-specific auditory brainstem potential thresholds (ABR) were determined in young adult mice. One group (n = 8) underwent NIR irradiation (808 nm, 120 mW, 15 min) of the cochlea, followed by a 30 min noise exposure (5-20 kHz, 115 dB SPL). A post-NIR treatment was administered for 30 min immediately following the noise trauma. After 14 days, hearing loss was determined by ABR measurements. The results were compared with a trauma-only group (n = 8) and an untreated control group (n = 5). Subsequently, the spiral ganglion neuron density was investigated.
resultsA peri-traumatic NIR treatment resulted in a significantly lower hearing loss compared to the trauma-only group. Hearing protection in these animals significantly exceeded the effect of an exclusive pre- or post-treatment across all frequencies. A loss of spiral ganglion neurons in the trauma-only group was observed, which was significantly rescued by the peri-traumatic NIR treatment.
conclusionsA single peri-traumatic NIR treatment seems to be the more effective approach for the preservation of hearing thresholds after noise trauma compared to an isolated pre- or post-treatment. One target of the protective effect seems to be the spiral ganglion.
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