ArticleBrain sciences2025
Examining Insula-Default Mode Network Functional Connectivity and Its Relationship with Heart Rate Variability.
Article in Brain sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed.
- A Causal Association Study Between Brain Imaging Features and the Risk of Large Artery Atherosclerosis: A Two-sample Mendelian Randomization Study.Journal of molecular neuroscience : MN · 2026Article
- Through Massage to the Brain-Neuronal and Neuroplastic Mechanisms of Massage Based on Various Neuroimaging Techniques (EEG, fMRI, and fNIRS).Journal of clinical medicine · 2026Review
- Research hotspots and trend of the heart-brain axis by MRI: a bibliometric analysis.Frontiers in cardiovascular medicine · 2026Article
- Central autonomic network-heart interplay in anorexia nervosa. A cross-spectral dynamic causal modeling study.NeuroImage. Clinical · 2026Article
- The Effect of Transcranial Direct Current Stimulation on Basketball Performance-A Scoping Review.Journal of clinical medicine · 2025Review
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Authors and funding
5 authors.
Funding
Abstract
backgroundThe Default Mode Network (DMN) is involved in self-referential and emotional processes, while the insula integrates emotional and interoceptive signals. Functional connectivity between the insula and the DMN is proposed to enhance these processes by linking internal bodily states with self-referential thoughts and emotional regulation. Heart Rate Variability (HRV), a measure of parasympathetic regulation of cardiac activity, has been associated with the capacity to regulate autonomic arousal. This study explored the relationship between insula-DMN functional connectivity and HRV. We hypothesized that (1) insula's functional activity and volume would be related to HRV; (2) insula activation would be functionally connected with the DMN; and (3) stronger insula-DMN connectivity would correlate with higher HRV.
methodsForty-three healthy adults underwent a structural and functional MRI acquisition to assess insula-DMN connectivity during resting state. HRV was measured also at rest using the BIOPAC system.
resultsA significant positive correlation was found between insula-DMN connectivity, but no correlation was observed between insula-DMN connectivity and HRV. We also found a positive significant association between left insula volume and HRV.
conclusionsThese findings suggest that while the AI and DMN are functionally interconnected, this connectivity may not be directly related to HRV. The results highlight the complexity of the relationship between brain connectivity and autonomic function, suggesting that other factors may influence HRV.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.