ArticleBrain sciences2024
White Matter-Gray Matter Correlation Analysis Based on White Matter Functional Gradient.
Article in Brain sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThe spontaneous fluctuations in functional magnetic resonance imaging (fMRI) signals of the brain's gray matter (GM) have been interpreted as representations of neural activity variations. In previous research, white matter (WM) signals, often considered noise, have also been demonstrated to reflect characteristics of functional activity and interactions among different brain regions. Recently, functional gradients have gained significant attention due to their success in characterizing the functional organization of the whole brain. However, previous studies on brain functional gradients have predominantly focused on GM, neglecting valuable functional information within WM.
methodsIn this paper, we have elucidated the symmetrical nature of the functional hierarchy in the left and right brain hemispheres in healthy individuals, utilizing the principal functional gradient of the whole-brain WM while also accounting for gender differences.
resultsInterestingly, both males and females exhibit a similar degree of asymmetry in their brain regions, albeit with distinct regional variations. Additionally, we have thoroughly examined and analyzed the distribution of functional gradient values in the spatial structure of the corpus callosum (CC) independently, revealing that a simple one-to-one correspondence between structure and function is absent. This phenomenon may be associated with the intricacy of their internal structural connectivity.
conclusionsWe suggest that the functional gradients within the WM regions offer a fresh perspective for investigating the structural and functional characteristics of WM and may provide insights into the regulation of neural activity between GM and WM.
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