ArticleBrain sciences2024
Non-Linear Effects of Acute Sleep Deprivation on Spatial Working Memory: Cognitive Depletion and Neural Compensation.
Article in Brain sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.
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Who cites it
6 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The Caffeinated Brain Part 1: The Effects of Caffeine on Event-Related Potentials (ERPs)-A Systematic and Mechanistic Review.Nutrients · 2026Pooled it
- Effects of sleep deprivation on heart rate variability: a systematic review and meta-analysis.Frontiers in neurology · 2025Pooled it
- Sleepiness During Night Shifts and Nurses' Self-Reported Cognitive Control, Cognitive Flexibility, and Handover Effectiveness: A Cross-Sectional Study.International nursing review · 2026Article
- Neurophysiology of Sleep-Deprivation Part 1: Effects of Sleep-Deprivation on Event-Related Potentials (ERPs)-Systematic and Mechanistic Review.Journal of clinical medicine · 2026Review
- Caffeine and modafinil counteract sleep deprivation through distinct neurocognitive pathways: an ERP study of object working memory.Frontiers in human neuroscience · 2026Article
- Neural Correlates of Burnout Syndrome Based on Electroencephalography (EEG)-A Mechanistic Review and Discussion of Burnout Syndrome Cognitive Bias Theory.Journal of clinical medicine · 2025Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSpatial working memory is crucial for processing visual and spatial information, serving as a foundation for complex cognitive tasks. However, the effects of prolonged sleep deprivation on its dynamics and underlying neural mechanisms remain unclear. This study aims to investigate the specific trends and neural mechanisms underlying spatial working memory alterations during 36 h of acute sleep deprivation.
methodsTwenty participants underwent a 36 h protocol of acute sleep deprivation. Utilizing the spatial 2-back task for assessing spatial working memory, combined with event-related potential (ERP) technology, we compared behavioral and neural responses at four critical time points-before deprivation, and after 12, 24, and 36 h of sleep deprivation-to uncover dynamic cognitive changes.
resultsThe findings indicate that the impact of sleep deprivation on spatial working memory exhibits significant temporal dependence. After 24 h of deprivation, both behavioral performance and ERP component amplitudes showed significant declines. During the period from 24 to 36 h, the amplitudes of the P2, N2, and P3 components exhibited a recovery trend, potentially reflecting neural compensatory mechanisms.
conclusionsThe impact of 36 h acute sleep deprivation on spatial working memory is characterized by time-dependent and phase-specific effects. Initially, sleep deprivation leads to severe cognitive depletion, followed by an adaptive compensatory phase where neural mechanisms may partially restore function. These findings highlight the non-linear nature of cognitive impairment due to sleep deprivation, involving complex self-regulatory and compensatory mechanisms, with implications for understanding cognitive resilience and adaptive processes.
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