ArticleBioengineering (Basel, Switzerland)2025
A Pilot Study on the Age-Dependent, Biomechanical Properties of Longitudinal Ligaments in the Human Cervical Spine.
Article in Bioengineering (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Macrophage-driven pathological ossification of the posterior longitudinal ligament: mechanistic insights and therapeutic opportunities.Bone research · 2026Review
- Article
- Analysis of Biomechanical Characteristics of Bone Tissues Using a Bayesian Neural Network: A Narrative Review.Journal of functional biomaterials · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
The cervical spine ligaments, including the anterior longitudinal ligament (ALL) and posterior longitudinal ligament (PLL), play a key role in maintaining spinal stability by limiting excessive movements. This study investigates how ageing affects the mechanical properties of these ligaments. We analysed 33 samples from 12 human cervical spines (15 ALL, 18 PLL), averaging data from the same donors for independent analysis, resulting in 18 final samples (8 ALL, 10 PLL). To explore age-related changes, we classified the samples into two groups-below and above 50 years old-aligning with the peak incidence of major musculoskeletal disorders. The investigation concentrated on the effects of age on four mechanical parameters of the uniaxial stress-stretch curve: initial tangent stiffness (E0), maximum tangent stiffness (Em), ultimate stress (Pu) and ultimate stretch (λu). When the age effect is neglected, then the behaviours of both the ALL and PLL appeared similar. However, when introducing age as a variable into the context of the ALL and PLL, statistically significant differences became evident. The findings underscored a reduction in maximum tangent stiffness (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.