ArticleBioengineering (Basel, Switzerland)2025
Skull Impact on Photoacoustic Imaging of Multi-Layered Brain Tissues with Embedded Blood Vessel Under Different Optical Source Types: Modeling and Simulation.
Article in Bioengineering (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed.
- Water-sensitive photoacoustic temperature characterization at 960 nm in cerebral vascular phantoms with CT co-registration.Photoacoustics · 2026Article
- Monte Carlo-Based Optimization of Multi-Source Illumination for Photoacoustic Signal Generation in Human Gray-Matter Vessels.Journal of biophotonics · 2026Article
- Multiscale photoacoustic imaging of stroke in preclinical models and future directions toward clinical translation [Invited].Biomedical optics express · 2026Review
- Optoacoustically augmented magnetic guidewire for radiation-free minimally invasive therapies.Science advances · 2026Article
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4 authors.
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Abstract
Skulls with high optical scattering and acoustic attenuation are a great challenge for photoacoustic imaging for human beings. To explore and improve photoacoustic generation and propagation, we conducted the photoacoustic simulation and image reconstruction of the multi-layer brain model with an embedded blood vessel under different optical source types. Based on the optical simulation results under different types of optical sources, we explored the characteristics of reconstructed images obtained from acoustic simulations with and without skull conditions. Specifically, we focused on the detection of blood vessels and evaluated the image reconstruction features, morphological characteristics, and intensity of variations in the target vessels using optical and acoustic simulations. The results showed that under the initial PA signals, the types of optical source types corresponding to the strongest and weakest photoacoustic signals at different positions within the target region were consistent, while the optical source types were different in the reconstructed images. This study revealed the characteristics of acoustic signal transmission with and without skull conditions and its impact on image reconstruction. It further provides a theoretical basis for the selection of optical sources.
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