Microdifferential Pressure Measurement Device for Cellular Microenvironments.

Mami Akaike, Jun Hatakeyama, Yoichi Saito, Yoshitaka Nakanishi, Kenji Shimamura, Yuta Nakashima

Abstract read

In one paragraph

Article in Bioengineering (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Measuring intraventricular pressure in developing mouse embryos: Uncovering a repetitive mechanical cue for brain development.Development, growth & differentiation · 2025
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mami AkaikeGraduate School of Science and Technology, Kumamoto University, 2-39-1 Kurokami, Chuo-ku, Kumamoto 860-8555, Japan.

Jun HatakeyamaInstitute of Molecular Embryology and Genetics, Kumamoto University, 2-2-1 Honjyo, Chuo-ku, Kumamoto 860-0811, Japan.

Yoichi SaitoFaculty of Advanced Science and Technology, Kumamoto University, 2-39-1 Kurokami, Chuo-ku, Kumamoto 860-8555, Japan.ORCID 0000-0001-9097-7656

Yoshitaka NakanishiFaculty of Advanced Science and Technology, Kumamoto University, 2-39-1 Kurokami, Chuo-ku, Kumamoto 860-8555, Japan.ORCID 0000-0002-7975-3595

Kenji ShimamuraInstitute of Molecular Embryology and Genetics, Kumamoto University, 2-2-1 Honjyo, Chuo-ku, Kumamoto 860-0811, Japan.

Yuta NakashimaFusion Oriented Research for Disruptive Science and Technology, Japan Science and Technology Agency, 5-3, Yonbancho, Chiyoda-ku, Tokyo 102-8666, Japan.ORCID 0000-0003-3151-4963

Funding

Japan Science and Technology Agency JPMJFR204BJapan Society for the Promotion of Science 19H04784Japan Society for the Promotion of Science 19KK0096Japan Society for the Promotion of Science 21K06190Japan Society for the Promotion of Science 23H04712Kumamoto University Interdisciplinary Research Project of the Institute of Industrial NanomaterialsKumamoto University Research Promotion for SDGsKumamoto University Terada Torahiko Fellowship ProgramMurata Science and Education Foundation Murata Science and Education FoundationTakeda Science Foundation Takeda Science Foundation

6 · The paper itself

Abstract

Mechanical forces influence cellular proliferation, differentiation, tissue morphogenesis, and functional expression within the body. To comprehend the impact of these forces on living organisms, their quantification is essential. This study introduces a novel microdifferential pressure measurement device tailored for cellular-scale pressure assessments. The device comprises a glass substrate and a microchannel constructed of polydimethylsiloxane, polytetrafluoroethylene tubes, a glass capillary, and a microsyringe pump. This device obviates the need for electrical measurements, relying solely on the displacement of ultrapure water within the microchannel to assess the micropressure in embryos. First, the device was subjected to arbitrary pressures, and the relationship between the pressure and the displacement of ultrapure water in the microchannel was determined. Calibration results showed that the displacement

Indexed as

brain pressureembryomechanical forcemicrodifferential pressure sensormicroenvironment

Identifiers

PMID39851277

DOI10.3390/bioengineering12010003

PMCPMC11763269

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.