ArticleEnvironmental science & technology2025
An Overview of Potential Alternatives for the Multiple Uses of Per- and Polyfluoroalkyl Substances.
Article in Environmental science & technology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- Recent advances in the degradation of polytetrafluoroethylene (PTFE) at low temperature (≤100 °C).Chemical science · 2026Review
- Understanding the Defluorination Mechanism of Per- and Polyfluoroalkyl Substances in Wastewater: From Microscopic Process to Practical Application.Small (Weinheim an der Bergstrasse, Germany) · 2026Review
- [Determination of 29 per- and polyfluoroalkyl substances and 22 organophosphate esters and diester metabolites in human serum by high-throughput solid-phase extraction- ultra performance liquid chromatography- high resolution mass spectrometry].Se pu = Chinese journal of chromatography · 2026Article
- Article
- Preserved and Accessible: Quantifying PFAS in Formalin-Fixed and Paraffin-Embedded Tissues for Retrospective Exposure and Dose Assessment.Environmental science & technology · 2026Article
- Article
- Allowing Unlimited PFAS Manufacturing Contradicts the Core Intention of the European Union's PFAS Restriction Proposal.Environmental science & technology · 2026Article
- Per- and polyfluoroalkyl substances (PFAS): persistence, toxicity, and emerging solutions.Bioprocess and biosystems engineering · 2026Review
- A new multi-residue method for PFAS analysis in wastewater for environmental and public health risk assessment.Analytical and bioanalytical chemistry · 2026Article
- Global Disparities in the Regulation of PFASs: The Risk of Shifting the PFAS Pollution Burden to Developing Countries.Environmental science & technology · 2026Review
- Atmospheric transport and deposition of PFAS in East Antarctica: Evidence from snow transect measurements and a multidecadal record.Science advances · 2026Article
- The PFAS roadmap-Navigating a path together to improved management.Sustainability science and technology · 2026Article
- Article
- Rethinking sustainable pathways for PFAS.Nature chemistry · 2026Article
- Microbial and molecular approaches for PFAS transformation in soils: prospects and limitations.RSC advances · 2026Review
- PFAS exposure and reproductive dysfunction: implications for outcomes in assisted reproductive technologies.Frontiers in endocrinology · 2026Review
- A Cyclodextrin-Mediated Host-Guest Interactions Within α-Hemolysin Nanopore Platform for PFAS Identification.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Predicting the critical micelle concentration of binary surfactant mixtures using machine learning.Journal of cheminformatics · 2025Article
- High-Throughput Small-Scale Platform for Synthesis, Characterization, and Modeling of Per- and Polyfluoroalkyl Substances Analogs.Environmental science & technology letters · 2025Article
- Exploring the Association Between Per- and Polyfluoroalkyl Substances Exposure and the Risk of Stroke: A Systematic Investigation Using NHANES Data Analysis, Network Toxicology and Molecular Docking Approaches.Brain and behavior · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Per- and polyfluoroalkyl substances (PFAS) are used in a wide range of different industrial and consumer applications. However, due to their extreme environmental persistence and their impacts on human and ecosystem health, PFAS have been subject to many regulatory activities, including initiatives to incentivize industry to transition toward PFAS-free alternatives. Although efforts have been made to map all uses of PFAS, work is still needed to provide an overview of their potential alternatives. Based on the functional substitution approach, this study develops an online database that documents all known uses of PFAS, describes the functions provided by PFAS in these uses, lists potential alternatives that can deliver equivalent or similar functions to PFAS, and evaluates the suitability of the identified alternatives to replace PFAS. Overall, the database lists 325 different applications of PFAS across 18 use categories. In total, 530 PFAS-free alternatives are identified. Based on a screening of potential concerns of the identified alternatives, their performance compared to PFAS, and their availability on the market, it is concluded that potentially suitable alternatives to PFAS are available for 40 different applications. For 83 applications, no alternatives could be identified at the time of the study and should be the focus of further research activities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.