ArticleeLife2025
Risk factors affecting polygenic score performance across diverse cohorts.
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In one paragraph
Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7citing papers in PubMed
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed.
- Pervasive interactions between exposures and polygenic risk can inform more effective clinical and behavioral interventions.Nature genetics · 2026Article
- Evidence standards for multi-ancestry polygenic prediction.Genome biology · 2026Review
- AI-driven big data analysis and predictive modeling of infectious disease immunity: from correlates to causal, multiscale understanding.Archives of microbiology · 2026Review
- CalPred yields calibrated intervals for polygenic risk prediction.medRxiv : the preprint server for health sciences · 2026Article
- Polygenic risk score for type 2 diabetes shows context-dependent effects across populations.Nature communications · 2025Article
- The PRIMED Consortium: Reducing disparities in polygenic risk assessment.American journal of human genetics · 2024Article
- Dual exposure-by-polygenic score interactions highlight disparities across social groups in the proportion needed to benefit.medRxiv : the preprint server for health sciences · 2024Article
Corrections and comments
- Update of
Authors and funding
22 authors.
Daniel HuiDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.ORCID https://orcid.org/0000-0002-8023-7352
Scott DudekDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
Krzysztof KirylukDivision of Nephrology, Department of Medicine, Columbia University, New York, United States.
Theresa L WalunasDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States.
Iftikhar J KulloDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, United States.
Wei-Qi WeiDepartment of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, United States.
Hemant TiwariDepartment of Pediatrics, University of Alabama at Birmingham, Birmingham, United States.
Josh F PetersonDepartment of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, United States.
Wendy K ChungDepartments of Pediatrics and Medicine, Columbia University Irving Medical Center, Columbia University, New York, United States.
Brittney H DavisDepartment of Neurology, School of Medicine, University of Alabama at Birmingham, Birmingham, United States.
Atlas KhanDivision of Nephrology, Department of Medicine, Columbia University, New York, United States.
Leah C KottyanThe Center for Autoimmune Genomics and Etiology, Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, United States.
Nita A LimdiDepartment of Neurology, School of Medicine, University of Alabama at Birmingham, Birmingham, United States.
Qiping FengDivision of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, United States.ORCID https://orcid.org/0000-0002-6213-793X
Megan J PuckelwartzCenter for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States.
Chunhua WengDepartment of Biomedical Informatics, Vagelos College of Physicians & Surgeons, Columbia University, New York, United States.
Johanna L SmithDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, United States.
Elizabeth W KarlsonDivision of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, United States.
Regeneron Genetics Center
Penn Medicine BioBank
Gail P JarvikDepartments of Medicine (Medical Genetics) and Genome Sciences, University of Washington Medical Center, Seattle, United States.
Marylyn D RitchieDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.ORCID https://orcid.org/0000-0002-1208-1720
Funding
Phenotypic Diversity in COVID-19UL1TR001878 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2016 to 2025
$102.4MThe eMERGE Risk Assessment Network - Coordinating CenterU01HG011166 · NHGRI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Niall John Lennon, Joseph F. Peterson · 2020 to 2026
$16.8MGenomic Basis of Susceptibility to COVID-19 Infection and its ComplicationsU01HG006379 · NHGRI · MAYO CLINIC ROCHESTER · PI Richard R. Sharp · 2011 to 2026
$16.5MFinding Genomic Profiles of COVID-19 Phenotypes from the EHRU01HG008685 · NHGRI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIZABETH W KARLSON, Matthew S Lebo · 2015 to 2026
$13.6MVariation, Function, and Disease Supplement ProgramU01HG008657 · NHGRI · UNIVERSITY OF WASHINGTON · PI David Russell Crosslin, Gail Pairitz Jarvik · 2015 to 2026
$13.4MOMOP information model for eMERGE phenotypingU01HG008680 · NHGRI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Wendy K Chung, GEORGE M HRIPCSAK · 2015 to 2026
$13.3MPharmacogenomics of HIV TherapyR01AI077505 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HAAS, DAVID W · 2008 to 2025
$12.3MThe molecular genetic analysis of human obesityR01DK052431 · NIDDK · ROCKEFELLER UNIVERSITY · PI CHUNG, WENDY K, LEIBEL, RUDOLPH L · 1996 to 2020
$11.6MTissue Repository CoreP30AR070549 · NIAMS · CINCINNATI CHILDRENS HOSP MED CTR · PI Grant Sanford Schulert · 2016 to 2026
$7.7MThe Electronic Medical Records and Genomics (eMERGE) Network Phase III Coordinating Center (U01)U01HG008701 · NHGRI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI PETERSON, JOSEPH F. · 2015 to 2019
$7.1MVGER, the Vanderbilt Genome-Electronic Records ProjectU01HG008672 · NHGRI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DENNY, JOSHUA C., RODEN, DAN M · 2015 to 2019
$5.1MBetter Outcomes for Children: Promoting Excellence in Healthcare Genomics to Inform PolicyU01HG008666 · NHGRI · CINCINNATI CHILDRENS HOSP MED CTR · PI HARLEY, JOHN BARKER · 2015 to 2019
$4.2MBrigham and Women's Hospital U01HG008685Cincinnati Children's Hospital Medical Center U01HG008666Columbia University Health Sciences U01HG008680Group Health Cooperative/University of Washington U01HG008657Mayo Clinic U01HG006379NCATS NIH HHS UL1 TR001878NHGRI NIH HHS U01 HG006379NHGRI NIH HHS U01 HG008657NHGRI NIH HHS U01 HG008666NHGRI NIH HHS U01 HG008672NHGRI NIH HHS U01 HG008673NHGRI NIH HHS U01 HG008680NHGRI NIH HHS U01 HG008685NHGRI NIH HHS U01 HG008701NHGRI NIH HHS U01 HG011166NHLBI NIH HHS R01 HL169458NIAID NIH HHS R01 AI077505NIAMS NIH HHS P30 AR070549NIA NIH HHS R01 AG033067NIDDK NIH HHS DK52431NIDDK NIH HHS R01 DK052431NIH HHS AI077505NIH HHS HL169458NIH HHS U01 HG008680NIH HHS U01 HG011166Northwestern University U01HG008673Vanderbilt University Medical Center U01HG008672Vanderbilt University Medical Center serving as the Coordinating Center U01HG008701
Abstract
Apart from ancestry, personal or environmental covariates may contribute to differences in polygenic score (PGS) performance. We analyzed the effects of covariate stratification and interaction on body mass index (BMI) PGS (PGS
Indexed as
Body Mass IndexMultifactorial InheritanceAdultAfrican PeopleAgedCohort StudiesFemaleGenome-Wide Association StudyHumansMaleMiddle AgedRisk FactorsWhite Peoplebody mass indexcomputational biologygene–environmentgeneticsgenomicsGWAShumanpolygenic scoressystems biology
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.