Evidence map›Paper›PMID 39851125›Full record

ReviewMicroRNA (Shariqah, United Arab Emirates)2025

Extrahepatic and Circulating miR-122: Diagnostic Implications and Future Directions.

Rachel Sarah Royfman, Joseph Riley McTague, Meghana Ranabothu, Bindu Menon

Abstract readReview
PubMed Publisher
In one paragraph

Review in MicroRNA (Shariqah, United Arab Emirates), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Rachel Sarah RoyfmanDepartment of Medicine, The Ohio State University, Columbus, OH, USA.
Joseph Riley McTagueDepartment of Emergency Medicine, University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA.
Meghana RanabothuDepartment of Medical Education, University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA.
Bindu MenonDepartment of Medical Education, University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Research on microRNAs is constantly expanding and evolving due to their role in the regulation of gene expression. miR-122, a 22-nucleotide microRNA, was first discovered as a liver-specific miRNA. Subsequently, it was found to be present in a wide range of tissues, such as the breast, testes, ovaries, and heart. The research on miR-122 in the liver has been extensive over the past few decades, leading to several important discoveries. However, its role in extrahepatic tissues is largely incompletely understood. Therefore, in light of the established clinical relevance of miR-122 as a potential biomarker and/or drug target in the liver, available information on miR-122 is compiled as it pertains to health and disease. This review discusses novel information generated in recent years and the corresponding progress in our understanding of the physiology of extrahepatic miR-122.

Indexed as

MicroRNAsAnimalsBiomarkersGene Expression RegulationHumansLiverBiomarkersMicroRNAsMIRN122 microRNA, humancirculating mRNAmicro-RNAmiR-122non-coding RNAspost-transcriptional gene regulation.

Identifiers

PMID39851125

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.